AI Article Synopsis
- Both serotonin (5-HT) and the neuropeptide SCPb enhance inward sodium currents while affecting potassium currents in B15 neurons, while FMRFamide has the opposite effect on sodium currents.
- cAMP appears to play a significant role in modulating these ionic currents due to its increased levels from 5-HT and SCPb applications.
- The research indicates that multiple second-messenger systems, including phospholipase C/protein kinase C pathways and arachidonic acid, contribute to the varied responses of B15 neurons to different chemical signals.
Article Abstract
Both 5-HT and the 9 amino acid neuropeptide SCPb modulate 3 ionic currents in B15, enhancing a voltage-dependent inward sodium current, decreasing an outward potassium current and increasing an inward rectifying potassium current. In contrast, FMRFamide decreases a voltage-dependent inward sodium current and increases an outward potassium current. We have also investigated the roles of several second-messenger systems that may be mediating the effects of these modulators. Bath application of membrane permeable analogs of cAMP enhance the voltage-dependent inward sodium current and both 5-HT and SCPb increase cAMP levels in B15, suggesting that cAMP may be mediating part of the observed effects of these transmitters on B15. Experiments with phorbol ester, a protein kinase inhibitor, and a phospholipase inhibitor suggest that the phospholipase C/protein kinase C cascade may decrease an outward potassium current. Thus, 5-HT and SCPb may activate multiple second-messenger systems to modulate 3 ionic currents in B15. Additional studies suggest that a cascade involving arachidonic acid may be involved in mediating part of the FMRFamide responses in B15. These studies are beginning to define molecular mechanisms whereby a neuron differentially modulates multiple ionic currents in response to distinct chemical messengers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569666 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.09-09-03218.1989 | DOI Listing |
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