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Background: As set out in Sustainable Development Goal 3.3, the target date for ending the HIV epidemic as a public health threat is 2030. Therefore, there is a crucial need to evaluate current epidemiological trends and monitor global progress towards HIV incidence and mortality reduction goals.
View Article and Find Full Text PDFRelationship Between Heart Rate and Perceived Stress in Intensive Care Unit Residents: Exploratory Analysis Using Fitbit Data.
JMIR Form Res
November 2024
Department of Systems and Enterprises, Stevens Institute of Technology, Hoboken, NJ, United States.
Background: Intensive care unit (ICU) residents are exposed to high stress levels due to the intense nature of their work, which can impact their mental health and job performance. Heart rate measured through wearable devices has the potential to provide insights into residents' self-reported stress and aid in developing targeted interventions.
Objective: This exploratory study aims to analyze continuous heart rate data and self-reported stress levels and stressors in ICU residents to examine correlations between physiological responses, stress levels, and daily stressors reported.
Busulfan Chemotherapy Downregulates TAF7/TNF-α Signaling in Male Germ Cell Dysfunction.
Biomedicines
September 2024
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
: Busulfan is an FDA-approved alkylating drug used in the chemotherapy of advanced acute myeloid leukemia. The precise mechanisms by which Busulfan kills spermatogonia stem cells (SSCs) are not yet completely understood. : Using a murine model, we evaluated Busulfan-induced apoptosis and DNA damage signaling between testis and ovary tissues.
View Article and Find Full Text PDFGender differences in adverse effects following the second dose of AstraZeneca COVID-19 vaccine: a cross-sectional study among healthcare workers.
Vaccine
December 2024
Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Epidemiology, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
Background: Vaccination in pandemic diseases, in addition to positive effects on controlling the prevalence and reducing the resulting socioeconomic effects, can have adverse effects with different intensity based on gender, type and dose of vaccine. We aimed to investigate gender differences in adverse effects following the second dose of AstraZeneca Covid-19 vaccine among healthcare workers (HWs).
Method: This cross-sectional study was conducted on 780 HWs who worked in two educational hospitals in Kermanshah city, western Iran, and had received the second dose of AstraZeneca vaccine.
Molecular signaling and clinical implications in the human aging-cancer cycle.
Semin Cancer Biol
November 2024
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States. Electronic address:
It is well documented that aging is associated with cancer, and likewise, cancer survivors display accelerated aging. As the number of aging individuals and cancer survivors continues to grow, it raises additional concerns across society. Therefore, unraveling the molecular mechanisms of aging in tissues is essential to developing effective therapies to fight the aging and cancer diseases in cancer survivors and cancer patients.
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