We studied the effects of 2-(hexyl(methyl)amino)methyl)pyridyl-3-dimethyl carbamate (OPDC), a structural analogue of aminostigmine oxalate, on memory formation in rats with toxic scopolamine-induced amnesia. It was shown that OPDC in non-toxic doses ((1)/215 LD50) has significant anti-amnesic action. Ipidacrine and galantamine in the doses similar to toxic doses ((1)/17 and (1)/6 of LD50, respectively) induced the retention of memory trace. Administration of aminostigmine ((1)/11 of LD50) induced unstable anti-amnesic effect in the model of scopolamine-induced amnesia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-014-2347-x | DOI Listing |
Publication Analysis
Top Keywords
structural analogue
8
scopolamine-induced amnesia
8
ld50 induced
8
possibility usage
4
usage aminostigmine
4
aminostigmine structural
4
analogue treatment
4
treatment toxic
4
toxic cognitive
4
cognitive disorders
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!