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Virulence profile of carbapenem-resistant strains by an model of .
Microbiol Spectr
January 2025
Microbiology and Virology, San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
is a significant healthcare-associated pathogen, notable for its diverse virulence and antibiotic resistance profiles. This study aimed to characterize the genotypic and phenotypic diversity of isolates and evaluate their virulence using the model. Biomass production, metabolic activity, capsule formation, and siderophore production were assessed in 27 .
View Article and Find Full Text PDFPioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.
Braz J Microbiol
January 2025
Department of Microbiology, Faculty of Science, Ain shams University, El-Khalyfa El-Mamoun Street, Abbasya, Cairo, Egypt.
Hospital surfaces are often contaminated with multidrug-resistant pathogenic bacteria that cause healthcare-associated infections and lead to increased mortality and morbidity. There is a need for new alternative antibacterial agents to overcome antibiotic resistance. Azadirachta indica and Simmondsia chinensis have been found to possess antibacterial activity and medicinal value.
View Article and Find Full Text PDFDissemination of arr-2 and arr-3 is associated with class 1 integrons in Klebsiella pneumoniae clinical isolates from Portugal.
Med Microbiol Immunol
January 2025
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
\nKlebsiella pneumoniae is a common pathogen of healthcare-associated infections expressing a plethora of antimicrobial resistance loci, including ADP-ribosyltransferase coding genes (arr), able to mediate rifampicin resistance. The latter has activity against a broad range of microorganisms by inhibiting DNA-dependent RNA polymerases. This study aims to characterise the arr distribution and genetic context in 138 clinical isolates of K.
View Article and Find Full Text PDFUse of Antimicrobial Photodynamic Therapy to Inactivate Multidrug-Resistant : Scoping Review.
Pharmaceutics
December 2024
Laboratorio de Microbiología Celular, Centro de Ciencias Médicas aplicadas, Facultad de Medicina y Ciencias de la Salud, Universidad Central de Chile, Lord Cochrane 418, Santiago 8330546, Chile.
is a Gram-negative bacillus responsible for a wide variety of potentially fatal infections and, in turn, constitutes a critical agent of healthcare-associated infections. Moreover, is characterized by multi-drug-resistant (MDR) bacteria, such as extended-spectrum beta-lactamases (ESBL) and carbapenemase (KPC) producer strains, representing a significant health problem. Because resistances make it difficult to eradicate using antibiotics, antimicrobial photodynamic therapy (aPDT) promises to be a favorable approach to complementing conventional therapy against MDR bacteria.
View Article and Find Full Text PDFEffect of Antimicrobial Wipes on Hospital-Associated Bacterial and Fungal Strains.
Infect Chemother
December 2024
Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea Seoul, Korea.
Background: Healthcare-associated infections (HAI) caused by multidrug-resistant organisms have emerged as a significant global issue, posing substantial challenges to healthcare systems. Low- and intermediate-level disinfectants are extensively utilized for cleaning and disinfecting surfaces in hospitals to mitigate environmental transmission of HAI. Therefore, the need for more effective and environmentally safe disinfectants is increasing.
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