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Prediction of acute myeloid leukemia prognosis based on autophagy features and characterization of its immune microenvironment.
Front Immunol
December 2024
School of Computer and Control Engineering, Yantai University, Yantai, Shandong, China.
Background: Autophagy promotes the survival of acute myeloid leukemia (AML) cells by removing damaged organelles and proteins and protecting them from stress-induced apoptosis. Although many studies have identified candidate autophagy genes associated with AML prognosis, there are still great challenges in predicting the survival prognosis of AML patients. Therefore, it is necessary to identify more novel autophagy gene markers to improve the prognosis of AML by utilizing information at the molecular level.
View Article and Find Full Text PDFThe development for emerging biomarkers of lymphangioleiomyomatosis.
Orphanet J Rare Dis
November 2024
Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Lymphangioleiomyomatosis (LAM) is a rare, slowly progressing, low-grade metastatic tumor primarily affecting women. Currently, vascular endothelial growth factor-D (VEGF-D) is the only validated diagnostic biomarker, enabling diagnosis of LAM without the need for lung biopsy in appropriate clinical settings. However, VEGF-D concentrations are normal in about 30% of patients, rendering it insufficient for diagnosing all cases of LAM.
View Article and Find Full Text PDFMolecular and Functional Assessment of and in Individuals with Tuberous Sclerosis Complex.
Genes (Basel)
November 2024
Human Genome and Stem Cell Research Center, Department of Genetics and Evolutionary Biology, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, Brazil.
Article Synopsis
- * A genetic diagnosis of TSC aids in confirming the clinical diagnosis and helps in managing care and monitoring patients.
- * In a study of 116 individuals, 91% had pathogenic DNA alterations in TSC-related genes, with detailed functional assessments revealing novel variants impacting TSC protein activity.
MLN4924 Suppresses head and neck squamous cell carcinoma progression by inactivating the mTOR signaling pathway via the NEDD8/CUL4/TSC2 axis.
Int J Biochem Cell Biol
December 2024
Department of General Surgery, The Third Hospital of Nanchang, Nanchang, Jiangxi 330000, China. Electronic address:
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with a five-year survival rate below 50 %. Standard treatments for HNSCC include surgery, radiotherapy, chemotherapy, and targeted therapies, but they still have significant limitations. Neddylation, a post-translational modification involving the attachment of NEDD8 (neural precursor cells expressed developmentally down-regulated 8) to proteins, is frequently dysregulated in HNSCC, thereby promoting tumor growth.
View Article and Find Full Text PDFAlcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis.
Reprod Toxicol
December 2024
UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA; Dept. Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. Electronic address:
Prenatal alcohol exposure is a leading cause of permanent neurodevelopmental disability and can feature distinctive craniofacial deficits that partly originate from the apoptotic deletion of craniofacial progenitors, a stem cell lineage called the neural crest (NC). We recently demonstrated that alcohol causes nucleolar stress in NC through its suppression of ribosome biogenesis (RBG) and this suppression is causative in their p53/MDM2-mediated apoptosis. Here, we show that this nucleolar stress originates from alcohol's activation of AMPK, which suppresses TORC1 and the p70/S6K-mediated stimulation of RBG.
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