Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.

Chem Commun (Camb)

Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology (INBT), The Johns Hopkins University, Baltimore, MD 21218, USA.

Published: June 2014

We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160079PMC
http://dx.doi.org/10.1039/c3cc49453eDOI Listing

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