AI Article Synopsis
- - Tobacco use is common in developing countries like India, leading to studies on genetic damage in smokers and smokeless tobacco users in rural Tamilnadu.
- - Researchers assessed DNA damage through various tests including chromosome aberrations and micronucleus frequency on blood samples and buccal cells.
- - Findings showed increased genetic damage in tobacco users, with 17% having a specific XRCC1 gene variant and 19% having a p53 gene variant, both linked to higher cancer risk.
Article Abstract
Inexpensive forms of tobacco are widely used in developing countries such as India. We have evaluated genotoxicity endpoints (chromosome aberrations, micronucleus frequency, comet assay) and polymorphisms of the XRCC1 and p53 genes among smokers and smokeless tobacco (SLT) users in rural Tamilnadu, South India. Cytogenetic, DNA damage and SNP analyses were performed on peripheral blood samples; micronucleus frequency was measured in peripheral blood and buccal mucosa exfoliated cells. Both categories of tobacco users had elevated levels of genotoxic damage. SNP analysis of tobacco users revealed that 17% carry the XRCC1 gln399gln genotype and 19% carry the p53 pro72pro genotype. Both genotypes are associated with increased risk of cancer.
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| http://dx.doi.org/10.1016/j.mrgentox.2014.04.007 | DOI Listing |
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