Several experiments show that prostatic fluid is continuously produced and it is drained from the prostate during urination and ejaculation. The mechanism which causes prostatic fluid to drain from the prostatic acini during urination is currently unclear. Also in current opinion such structures of the prostatic urethra as the urethral crest and the colliculus seminalis have no apparent functional significance. This article describes a mechanism for the draining of the prostatic acini that involves these prostatic urethral structures. It is hypothesized that the prostatic urethra works as a pump using the Venturi effect, in which urine is the carrying or motive liquid during voiding, in order to drain prostatic fluid (the carried liquid) from the acini. The urethral crest and the colliculus seminalis take part in controlling flow rates and liquid pressures for this pump to be effective. The calculated estimation of a pressure drop in the region of the colliculus seminalis during micturition was obtained using morphometric and uroflowmetric data and was used to confirm this hypothesis of prostatic acini drainage. As a consequence of this, a previously unknown function for these intra-prostatic urethral structures is described.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.mehy.2014.04.006 | DOI Listing |
Urol Pract
January 2025
Department of Urology, Mayo Clinic, Rochester, Minnesota.
Introduction: The US supply disruption of surgical irrigation fluids in September 2024 prompted the need for fluid conservation and potential deferral of urology procedures. We characterized fluid use in common endoscopic procedures to articulate recommendations for irrigation fluid stewardship and case prioritization during fluid shortages.
Methods: We reviewed case volumes and irrigation fluid use for endoscopic urological procedures at our institution during January-September 2024.
Epigenomics
January 2025
Cancer Research Group, School of Life Health and Chemical Sciences, The Open University UK, Milton Keynes, UK.
Background: Aggressive Variant Prostate Cancers (AVPCs) are incurable malignancies. Platinum-based chemotherapies are used for the palliative treatment of AVPC. The Polycomb Repressive Complex 2 (PRC2) promotes prostate cancer progression histone H3 Lysine 27 tri-methylation (H3K27me3).
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Urology and Metabolic Rehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University, Xixia Zhuang, Badachu, Shijingshan District, Beijing, China.
Prostate cancer is epithelial malignant prostate hyperplasia caused by a tumor. We found prostate cancer GSE141551 and GSE200879 profiles from gene expression omnibus database, followed by differentially expressed genes (DEGs) analysis, weighted gene co-expression network analysis, protein-protein interaction analysis, gene function enrichment analysis, and comparative toxicology database analysis. Finally, the gene expression heat map was drawn, and miRNA information regulating core DEGs was retrieved.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Emergency Medicine, The First People's Hospital of Kunshan, Kunshan, China.
Background: A liver abscess caused by hypervirulent can lead to multiple invasive extrahepatic infections, including lung abscesses, endophthalmitis, brain abscesses, and necrotizing fasciitis. This condition, known as liver abscess invasion syndrome, progresses rapidly and is associated with severe illness, high disability rates, and significant mortality. However, bloodstream infections with co-infection involving carbapenem-resistant are exceedingly rare.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, , 11829, Cairo, Egypt.
Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements in cancer therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, and targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate cancer (PCa) is unfavorable since it is a perilous and lethal malignancy.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!