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| http://dx.doi.org/10.1093/nar/17.16.6761 | DOI Listing |
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Exploring oral candidiasis among cancer patients undergoing chemotherapy in eastern Iran.
Iran J Microbiol
December 2024
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Background And Objectives: Understanding the epidemiology of species among cancer patients is crucial for preventing invasive infections. This study aimed to identify species and assess risk factors among cancer patients receiving chemotherapy in Birjand, eastern Iran.
Materials And Methods: The samples were obtained from the oral cavity of 140 patients and the initial identification of species was carried out through fungal cultures.
Genetic profiling of Plasmodium falciparum antigenic biomarkers among asymptomatic pregnant women on intermittent preventive treatment with sulfadoxine-pyrimethamine from southwest Nigeria.
Placenta
January 2025
Department of Pharmacology, Babcock University, Ilishan-Remo, Ogun, Nigeria; Centre for Advanced Medical Research and Biotechnology, Babcock University, Ilishan-Remo, Ogun, Nigeria.
Introduction: The genetic complexity of Plasmodium falciparum is contributory to the emergence of drug resistant-parasites. Intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) in malaria endemic settings is recommended by WHO. This study evaluated the prevalence of Plasmodium falciparum multidrug resistance-1 gene (Pfmdr-1), genetic diversity of merozoite surface proteins (msp-1, msp-2) and glutamate-rich protein (glurp) among pregnant women with sub-patent parasitaemia from southwest Nigeria.
View Article and Find Full Text PDFGenetic diversity of Plasmodium falciparum and Plasmodium vivax field isolates from the Nowshera district of Pakistan.
Malar J
November 2024
Department of Biochemistry Abdul Wali, Khan University Mardan, Mardan, Pakistan.
Article Synopsis
- The study investigates the genetic diversity of malaria parasites, specifically focusing on the Pfmsp1 and Pfmsp2 genes in Plasmodium falciparum and the Pvmsp-3α gene in Plasmodium vivax from Nowshera District, Pakistan.
- Blood samples from 124 malaria patients were collected and analyzed using genomic techniques, uncovering numerous distinct alleles and variants in both P. falciparum (21 alleles) and P. vivax (4 allelic variants).
- The findings indicate moderate to high allelic diversity among the malaria parasites in the area, marking the first molecular characterization of these genotypes in this specific region.
Exploring the relationship between genetic diversity and antimalarial drugs resistance markers in a malaria-endemic region of Burkina Faso.
Pan Afr Med J
November 2024
Université Joseph KI-ZERBO (UJKZ), Ouagadougou, Burkina Faso.
Introduction: the diversity of Plasmodium falciparum genotypes affects the dynamics of malaria transmission and is thought to be one of the factors hampering malaria control efforts. This study aimed to investigate the relationship between Plasmodium falciparum genetic diversity and chloroquine and sulfadoxine-pyrimethamine resistance markers in malaria endemic areas of Burkina Faso.
Methods: in a cross-sectional study, populations residing in Nouna health district were randomly recruited.
genetic markers associated with drug resistance from patients with treatment failure in the Southern part of Senegal in 2017.
Int J Mol Epidemiol Genet
June 2024
Parasitology-Mycology Department, Faculty of Medicine, University Cheikh Anta Diop Dakar, Senegal.
Artemisinin Combination Therapies (ACT) stand as the most potent antimalarial treatments. In response to the emergence of ACT-resistant malaria parasites in Southeast Asia, the World Health Organization (WHO) has recommended continuous monitoring of the effectiveness of ACT and other antimalarials. To address this need, we collected dried blood spots from malaria patients during a 42-days drug efficacy trial evaluating the efficacy of Artesunate plus Amodiaquine (ASAQ), Artemether Plus Lumefantrine (AL) and Dihydroarthemisinine plus Piperaquine (DHAPQ) on simple malaria in 2017.
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