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A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.
Clin Pharmacokinet
December 2024
Department of Anesthesiology, University of Groningen, University Medical Center Groningen, P. O. Box 30001, 9700 RB, Groningen, The Netherlands.
Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.
View Article and Find Full Text PDFUnraveling the causal pathways of maternal smoking and breastfeeding in the development of neuropsychiatric disorders: A Mendelian randomization perspective.
J Affect Disord
December 2024
Department of Sleep and Psychology, Chongqing Health Center for Women and Children, Chongqing 401147, China; Department of Sleep and Psychology, Women and Children's Hospital of Chongqing Medical University, 401147, China. Electronic address:
Background: Maternal smoking around birth (MSAB) and early-life breastfeeding (BAB) represent critical factors that may exert enduring effects on neuropsychiatric health. Although previous research has examined these exposures separately, the combined impact of both on disorders such as ADHD, ASD, BD, MDD, ANX, and SCZ remains unclear. This study aims to evaluate the causal relationships between MSAB and BAB and the risk of developing these neuropsychiatric disorders through Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFLow birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries.
Int J Cardiol Congenit Heart Dis
December 2024
Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Background And Aims: The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO).
Methods And Results: Thirty-nine ASO patients (age 24.4 ± 3.
[The effect of exposure to prenatal life events and social support levels on low birth weight in offspring: a prospective cohort study].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University/MOE Key Laboratory of Population Health Across Life Cycle/Anhui Provincial Key Laboratory of Environment and Population Health, Hefei230032, China.
To analyze the effects of exposure to life events and social support levels during different stages of pregnancy on low birth weight in offspring. From 2021 to 2023, pregnant women in early pregnancy who were registered with health cards in Linping District, Hangzhou City, were recruited and followed up. The Life Events Scale for Pregnant Women (LESPW) and Social Support Rating Scale (SSRS) were used to evaluate the exposure to life events and social support levels of pregnant women in early, middle and late pregnancy, respectively.
View Article and Find Full Text PDFAssociations of body composition at birth and accretion from 0-5 years with kidney function and volume at the 10-year follow-up: the Ethiopian iABC birth cohort.
Am J Clin Nutr
December 2024
Department of Internal Medicine, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia.
Background: Fat mass (FM) and fat-free mass (FFM) in early life are associated with later obesity and cardio-metabolic disease. This study aimed to assess the associations of FM and FFM at birth and conditional FM and FFM accretion from 0-5 years with kidney outcomes at the 10-year follow-up.
Method: The Ethiopian Infant Anthropometry and Body Composition (iABC) birth cohort included term infants born in Jimma town, with a birth weight ≥1500 grams, and having no congenital malformations.
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