Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cell.2014.04.008 | DOI Listing |
Publication Analysis
Top Keywords
mutant pten
8
pten cancer
4
cancer worse
4
worse tumor
4
tumor suppressors
4
suppressors block
4
block development
4
development cancer
4
cancer lost
4
lost tumor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!