AI Article Synopsis

  • Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, but little is known about the enzyme activities of catalase (CAT), carbonic anhydrases (CA), and xanthine oxidase (XO) in MF patients.
  • A study compared the enzyme activities of 32 MF patients to 26 healthy controls, revealing that CAT and CA activities were significantly lower in MF patients (p < 0.001), while XO activity showed no significant difference (p = 0.601).
  • The researchers suggest that measuring these enzyme levels could serve as a useful diagnostic tool for mycosis fungoides.

Article Abstract

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. In several studies the relationship between catalase (CAT), human cytosolic carbonic anhydrases (CA; hCA-I and hCA-II) and xanthine oxidase (XO) enzyme activities have been investigated in various types of cancers but carbonic anhydrase, catalase and xanthine oxidase activities in patients with MF have not been previously reported. Therefore, in this preliminary study we aim to investigate CAT, CA and XO activities in patients with MF. This study enrolled 32 patients with MF and 26 healthy controls. According to the results, CA and CAT activities were significantly lower in patients with mycosis fungoides than controls (p < 0.001) (p < 0.001). There was no significant difference in XO activity between patient and control group (p = 0.601). Within these findings, we believe these enzyme activity levels might be a potentially important finding as an additional diagnostic biochemical tool for MF.

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http://dx.doi.org/10.3109/14756366.2014.908292DOI Listing

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