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From natural herbal wisdom to nano innovation: Revolutionizing tumor treatment through metabolic reprogramming.
Biochim Biophys Acta Rev Cancer
January 2025
Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China. Electronic address:
In recent years, with the deepening understanding of the biological mechanisms underlying tumorigenesis, metabolic reprogramming has emerged as a pivotal process in cancer initiation, progression, and treatment resistance, gradually paving the way for new avenues in precision oncology. Natural herb ingredients, characterized by their multi-target engagement, low toxicity, and wide-ranging biological activities, exhibit unique advantages in anti-cancer therapy. Nonetheless, the clinical application of these components has been constrained by issues such as poor solubility, low bioavailability, and inadequate stability when administered through traditional delivery methods.
View Article and Find Full Text PDFLand-derived metals impact the survival and settlement of larval mussels.
Environ Pollut
January 2025
Cawthron Institute, 98 Halifax Street East, Nelson, 7010, New Zealand.
Global declines in wild mussel populations and production have been linked to the impacts of climate change and pollution. Summer die-offs of mussels (Perna canaliculus), spat retention issues, and a severe decline in mussel spat settlement have been reported in the Marlborough Sounds, an important area for mussel farming in New Zealand. Preliminary evidence suggests that naturally occurring contaminants and changing land use in the surrounding areas, could contribute to the decline of this species.
View Article and Find Full Text PDF3D printed Aloe barbadensis loaded alginate-gelatin hydrogel for wound healing and scar reduction: In vitro and in vivo study.
Int J Biol Macromol
January 2025
Department of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur 416006, MS, India. Electronic address:
Wounds are one of the most critical clinical issues in plastic surgery repair and restoration. Conventional wound dressing materials cannot absorb enough wound exudates and shield the site from microbial infection. Also, despite their healing prowess, bioactive molecules from medicinal plants are less bioavailable at the wound sites.
View Article and Find Full Text PDFScreening of different lamellar solids for the adsorption of phenolic compounds from grape pomace.
Food Chem
December 2024
Section of Food, Biochemical, Physiological and Nutritional Sciences, Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.
Grape pomace (GP) is recognized as a valuable source of polyphenols, prompting research into new therapeutic molecules while enhancing this by-product value. To address low stability and bioavailability issues of phenolic compounds, lamellar solids emerge as a promising approach for their loading and stabilization in food, cosmetic, and pharmaceutical applications. A solid phase adsorption procedure was developed here by comparing the properties of eight solids towards GP polyphenols.
View Article and Find Full Text PDFDesign, synthesis, and in-Silco ADME prediction of some novel bis(1,3,4-thiadiazoles) encapsulated lipid chitosan nano capsule decorative with magnetic nanoparticles and their potential anti-helicobacter pylori activity.
Int J Biol Macromol
January 2025
Supplementary General Sciences Department, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt.
Helicobacter pylori (H. pylori) is an extremely prevalent human pathogen globally that leads to severe illnesses. Sadly, the worldwide issue of H.
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