anti-Markovnikov hydroamination of alkenes catalyzed by a two-component organic photoredox system: direct access to phenethylamine derivatives.

Angew Chem Int Ed Engl

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290 (USA) http://www.chem.unc.edu/people/faculty/nicewicz/

Published: June 2014

Disclosed herein is a general catalytic system for the intermolecular anti-Markovnikov hydroamination of alkenes. By using an organocatalytic photoredox system, α- and β-substituted styrenes as well as aliphatic alkenes undergo anti-Markovnikov hydroamination. Heterocyclic amines were also successfully employed as nitrogen nucleophiles, thus providing a direct route to heterocyclic motifs common in medicinal agents.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073672PMC
http://dx.doi.org/10.1002/anie.201402443DOI Listing

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