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The mitochondriotropic antioxidants AntiOxBEN and AntiOxCIN are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts.
Biochim Biophys Acta Bioenerg
January 2025
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Mitochondrial dysfunction and increased reactive oxygen species (ROS) generation play an import role in different human pathologies. In this context, mitochondrial targeting of potentially protective antioxidants by their coupling to the lipophilic triphenylphosphonium cation (TPP) is widely applied. Employing a six‑carbon (C) linker, we recently demonstrated that mitochondria-targeted phenolic antioxidants derived from gallic acid (AntiOxBEN) and caffeic acid (AntiOxCIN) counterbalance oxidative stress in primary human skin fibroblasts by activating ROS-protective mechanisms.
View Article and Find Full Text PDFThirty years of StAR gazing: expanding the universe of the steroidogenic acute regulatory protein.
J Endocrinol
January 2025
W L Miller, Department of Pediatrics, Center for Reproductive Sciences, and Institute for Human Genetics University of California, San Francisco, United Kingdom of Great Britain and Northern Ireland.
Current understanding of the biology, biochemistry and genetics of the steroidogenic acute regulatory protein (StAR) and its deficiency state (congenital lipoid adrenal hyperplasia, lipoid CAH) involves the complex interplay of four areas of study: the acute regulation of steroidogenesis, clinical phenomena in lipoid CAH, the enzymatic conversion of cholesterol to pregnenolone in steroidogenic mitochondria, and the cell biology of StAR. This review traces the origins of these areas of study, describes how they have been woven into an increasingly coherent fabric, and tries to explore some remaining loose ends in this ongoing field of endocrine research. Abundant research from multiple laboratories establishes that StAR is required for the rapid, abundant steroidal responses of the adrenals and gonads, but all steroidogenic cells, especially the placenta, have StAR-independent steroidogenesis, whose basis remains under investigation.
View Article and Find Full Text PDFPediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface.
Cardiovasc Eng Technol
January 2025
School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Rm. 718, Philadelphia, PA, 19104, USA.
Purpose: Computational models of the cardiovascular system continue to increase in complexity. As more elements of the physiology are captured in multiscale models, there is a need to efficiently integrate subsystems. The objective of this study is to demonstrate the effectiveness of a coupling methodology, called functional mock-up interface (FMI), as applied to multiscale cardiovascular modeling.
View Article and Find Full Text PDFHepatitis Secondary to an Over-the-Counter Appetite Stimulant: A Case Report.
Cureus
November 2024
Pediatric Gastroenterology, Columbia University, New York, USA.
We present the case of a previously healthy 11-year-old boy who developed hepatitis in the setting of regular intake of Apetamin. Apetamin is an appetite stimulant not approved by the United States Food and Drug Administration that contains cyproheptadine, lysine, and multiple B vitamins. It is illegally imported into the United States and can be purchased online.
View Article and Find Full Text PDFCaregivers' Perceptions and Willingness to Utilize Telerehabilitation for Outpatient Consultation and Therapy for Pediatric Patients in a COVID-Referral Center in a Developing Country: A Cross-sectional Study.
Acta Med Philipp
November 2024
Department of Rehabilitation Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Article Synopsis
- The COVID-19 pandemic led to a rise in the use of telerehabilitation, which helps pediatric patients access necessary rehabilitation services remotely due to social distancing measures.
- Many pediatric patients struggle with telerehabilitation because they rely on caregivers for decision-making, and negative perceptions from those caregivers can hinder service utilization.
- This study aimed to assess caregivers' attitudes and willingness to engage in telerehabilitation for their children receiving outpatient care in a developing country, using a carefully designed survey to gather data.
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