AI Article Synopsis
- A novel microwave-mediated synthesis method was used to create a series of ethylene bis-imidazoles.
- Biological testing showed that these compounds have nanomolar potency against specific isozymes of carbonic anhydrase (CA VA and CA VII) in the human brain.
- The compounds also demonstrated strong selectivity, meaning they effectively targeted the intended isozymes while being less reactive with others in the brain.
Article Abstract
A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.
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| http://dx.doi.org/10.1039/c4cc02346c | DOI Listing |
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Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect.
Chem Commun (Camb)
June 2014
Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA-19140, USA.
Article Synopsis
- A novel microwave-mediated synthesis method was used to create a series of ethylene bis-imidazoles.
- Biological testing showed that these compounds have nanomolar potency against specific isozymes of carbonic anhydrase (CA VA and CA VII) in the human brain.
- The compounds also demonstrated strong selectivity, meaning they effectively targeted the intended isozymes while being less reactive with others in the brain.
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