Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (-)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011064 | PMC |
| http://dx.doi.org/10.3390/nu6041737 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construction of Silk Fibroin 3D Microfiber Scaffolds and Their Applications in Anti-Osteoporosis Drug Prediction.
Molecules
November 2024
School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
Silk microfiber scaffolds have garnered increasing interest due to their outstanding properties, with degumming being the process used to extract the sericin from the cocoon. In the present study, an attempt to tune the biodegradation period of silk through degumming with various sodium borohydride (NaBH) concentrations and degumming times was studied. We considered the process, the number of baths used, and the salt concentration.
View Article and Find Full Text PDFEthnobotanical usages, phytochemistry, pharmacology, and quality control of chuanxiong rhizoma: A review.
J Ethnopharmacol
January 2025
Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, Shaanxi, PR China. Electronic address:
Article Synopsis
- Chuanxiong Rhizoma (CX), derived from the Ligusticum chuanxiong plant, is recognized in traditional Chinese medicine for its healing properties related to blood circulation and pain relief, and has a history documented in the Chinese Pharmacopoeia from 1963 to 2020.
- This study aims to thoroughly review CX's botany, traditional applications, chemical compounds, pharmacological effects, toxicity, quality control, and its absorption and metabolism in the body.
- CX has over 400 identified compounds and is used in treating various health issues, especially those affecting the cardiovascular, liver, kidney, and nervous systems, exhibiting numerous pharmacological benefits like anti-inflammatory and antioxidant effects.
Aflatoxin B1 contamination reduces the saponins content and anti-osteoporosis efficacy of the traditional medicine Radix Dipsaci.
J Ethnopharmacol
January 2025
Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China. Electronic address:
Ethnopharmacological Relevance: The Radix Dipsaci, a traditional Chinese medicine with a history spanning over 2000 years in China, is widely recognized for its hepatorenal tonic properties, musculoskeletal fortifying effects, fracture healing capabilities, and its frequent application in the treatment of osteoporosis. Like many traditional Chinese herbal medicines, preparations from Radix Dipsaci are at risk of contamination by harmful mycotoxins such as aflatoxin B1.
Aims Of The Study: This study aims to evaluate the impact of aflatoxin B1 contamination on Radix Dipsaci in terms of changes in quality, efficacy of anti-osteoporosis and hepatorenal toxicity.
Natural Compounds for Bone Remodeling: Targeting osteoblasts and relevant signaling pathways.
Biomed Pharmacother
November 2024
Department of Spinal Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:
In the process of bone metabolism and bone remodeling, bone marrow mesenchymal stem cells (BM-MSCs) differentiate into osteoblasts (OBs) under certain conditions to enable the formation of new bone, and normal bone reconstruction and pathological bone alteration are closely related to the differentiation and proliferation functions of OBs. Osteogenic differentiation of BM-MSCs involves multiple signaling pathways, which function individually but interconnect intricately to form a complex signaling regulatory network. Natural compounds have fewer adverse effects than chemically synthesized drugs, optimize bone health, and are more suitable for long-term use.
View Article and Find Full Text PDFAn Overview on the Effects of Some Carotenoids on Health: Lutein and Zeaxanthin.
Curr Nutr Rep
December 2024
Department of Nutrition and Dietetics, School of Health Sciences, Ankara Medipol University, 06050, Altındağ, Ankara, Turkey.
Purpose Of Review: In this review, the chemical properties, nutritional sources, absorption mechanisms, metabolism, biosynthesis and promising health-related benefits of lutein and zeaxanthin were emphasized and some recommendations for the future studies are suggested.
Recent Findings: Lutein and zeaxanthin are phytochemical compounds in the carotenoid group and are synthesised only by plants. All mammals get lutein and zeaxanthin into their bodies by consuming plant-based foods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!