AI Article Synopsis
- The study investigates how associative memory in larvae can be formed using specific olfactory and reward signals, focusing on the activation of olfactory neurons and octopaminergic neurons.
- Researchers replaced traditional reward signals with thermogenetic stimulation and used optical techniques to activate a particular type of olfactory neuron.
- Findings reveal that stimulating just one type of olfactory receptor neuron can create olfactory memories that are similar to those formed through the activation of multiple receptors.
Article Abstract
It has been postulated that associative memory is formed by at least two sets of external stimuli, CS and US, that are transmitted to the memory centers by distinctive conversing pathways. However, whether associative memory can be induced by the activation of only the olfactory CS and a biogenic amine-mediated US pathways remains to be elucidated. In this study, we substituted the reward signals with dTrpA1-mediated thermogenetic activation of octopaminergic neurons and the odor signals by ChR2-mediated optical activation of a specific class of olfactory neurons. We show that targeted activation of the olfactory receptor and the octopaminergic neurons is indeed sufficient for the formation of associative olfactory memory in the larval brain. We also show that targeted stimulation of only a single type of olfactory receptor neurons is sufficient to induce olfactory memory that is indistinguishable from natural memory induced by the activation of multiple olfactory receptor neurons.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999485 | PMC |
| http://dx.doi.org/10.1038/srep04798 | DOI Listing |
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