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Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery. | LitMetric

Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery.

Expert Opin Biol Ther

Northeastern University, Pharmaceutical Sciences , 360 Huntington Avenue, 140 The Fenway Building, Boston, MA 02115 , USA.

Published: August 2014

AI Article Synopsis

  • * The review discusses the glycolytic pathway and highlights various targets for inhibiting glycolysis, along with new delivery methods to overcome existing challenges with current inhibitors.
  • * Targeting glycolysis is promising for cancer therapy, but issues like poor drug delivery and side effects are obstacles; using nanoparticles could improve how these inhibitors are delivered directly to tumors.

Article Abstract

Introduction: Cancer cells acclimatize to the harsh tumor microenvironment by altering cellular metabolism in favor of aerobic glycolysis. This process provides a source of energy and also generates essential components for macromolecular biosynthesis, which enables cellular survival. As the dependence of cancer cells on glycolysis affects tumorigenesis, it has become an attractive target for therapeutic intervention. Several preclinical studies have shown the effectiveness of using biological targets from the glycolytic pathway for anticancer therapy.

Areas Covered: This review provides an insight into the glycolytic pathway, highlighting potential targets for glycolytic inhibition. We then discuss recent advancement in delivery strategies that have the potential to circumvent some of the problems posed by current glycolytic inhibitors, enabling resurrection of abandoned therapeutic agents.

Expert Opinion: Targeting the glycolysis pathway is a tactical approach for cancer therapy. However, the current nonspecific therapeutic strategies have several drawbacks such as poor bioavailability, unfavorable pharmacokinetic profile and associated nonspecific toxicity, thereby limiting preclinical investigation. In recent years, nanoparticle systems have received recognition for the delivery of therapeutic agents directly to the tumor tissue. Thus, it is envisaged that this strategy can be expanded for the delivery of current glycolytic inhibitors specifically to tumor tissues providing improved anticancer activity.

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Source
http://dx.doi.org/10.1517/14712598.2014.912270DOI Listing

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