AI Article Synopsis
- The study focuses on establishing a dissolution determination method for multiple components in Liuwei Dihuang concentrated pills, specifically measuring gallic acid, loganin, paeoniflorin, and paeonol.
- The optimal conditions for this method were found to be using a paddle method with a specific hydrochloric acid solution at a precise rotation rate.
- The results showed that the dissolution curves of products from different pharmaceutical factories were significantly different, with similarity factor values mostly below 50, highlighting the need for improved quality evaluations in these products.
Article Abstract
With the content of gallic acid, loganin, paeoniflorin and paeonol as the indexes, to screen out dissolution determination conditions, establish the dissolution determination method for multi-index components in Liuwei Dihuang concentrated pills, calculate and map the accumulative dissolution curve, and then compare the dissolution of products from different pharmaceutical factories through the similarity factor (f2). According to the results, the optimum dissolution determination conditions were the paddle method, with 250 mL 0.1 mol x L(-1) hydrochloric acid as the dissolution medium, and a rotation rate of 100 r x min(-1). The similarity factor values (f2) of the dissolution curves of the four main components of Liuwei Dihuang concentrated pills from different pharmaceutical factories were mostly less than 50. This demonstrated a significant difference in the dissolution of Liuwei Dihuang concentrated pills from different pharmaceutical factories, and provided scientific basis for improving the equality evaluation of Liuwei Dihuang concentrated pills.
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