Brown recluse spiders are one of two types of spiders in the United States that can cause significant tissue damage and, in rare cases, death. Brown recluse spider bites are most often benign and self-limiting, but in a few cases can cause severe necrotic skin lesions.

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http://dx.doi.org/10.1097/01.JAA.0000443967.31234.87DOI Listing

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