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Emerging Artificial Synaptic Devices Based on Organic Semiconductors: Molecular Design, Structure and Applications.
ACS Appl Mater Interfaces
January 2025
The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha 410013, Hunan, People's Republic of China.
In modern computing, the Von Neumann architecture faces challenges such as the memory bottleneck, hindering efficient processing of large datasets and concurrent programs. Neuromorphic computing, inspired by the brain's architecture, emerges as a promising alternative, offering unparalleled computational power while consuming less energy. Artificial synaptic devices play a crucial role in this paradigm shift.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, USA.
Background: AD-NeuroScore is a validated metric that summarizes Alzheimer's disease (AD)-specific atrophy and can detect AD early, benchmark disease severity, predict and monitor AD progression, and can aid in testing the efficacy of therapeutic interventions using a single number (Kress, 2023). It meets criteria for translatability by using clinically available regional brain volumes as input (Ahdidan, 2015; Cavedo, 2022) and having patient and model-level interpretability (Pinto, 2022). Also, features can be reviewed by a neuroradiologist (Larson, 2019).
View Article and Find Full Text PDFCardiac dose comparison of abdominal and thoracic deep inspiration breath hold in adult female with left-sided breast cancer receiving radiation therapy: A systematic review and meta-analysis.
Radiography (Lond)
January 2025
School of Nursing, The Hong Kong Polytechnic University, Hong Kong. Electronic address:
Introduction: Deep inspiration breath hold technique has shown promise in reducing cardiac toxicity and improving patient outcomes. However, there is a lack of consensus regarding the implementation of abdominal breath hold technique and its impact on cardiac dose. This systematic review and meta-analysis aim to provide insights into the comparative effectiveness of abdominal and thoracic breath hold in mitigating cardiac toxicity during radiation therapy for left-sided breast cancer.
View Article and Find Full Text PDFPrimer on Health Equity Research in Health Economics and Outcomes Research: An ISPOR Special Interest Group Report.
Value Health
January 2025
Genentech, Inc, Alameda, CA, USA.
Objectives: Disparities in health and healthcare between more and less socially advantaged groups are pervasive, multidimensional, and far-reaching. The material and social conditions in which people are born, grow, work, live, and age are systematically associated with their health and with the volume, quality, and outcomes of care received by the vast majority of the general population, as well as by specific marginalized populations. The field of health economics and outcomes research (HEOR) has an important role in supporting health equity goals.
View Article and Find Full Text PDFRadiation-induced cardiac disease: Modern techniques to reduce cardiac toxicity.
Pract Radiat Oncol
January 2025
The Legacy Heritage Oncology Center & Dr Larry Norton Institute, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Medicine, Be'er Sheva, Israel.
Purpose: Continuous advancements in cancer management have resulted in increased long-term survival rates amongst cancer survivors and in turn have exposed the full extent of radiotherapy-associated morbidities. Radiation-induced coronary heart disease (RICHD) is one of the leading causes of morbidity and mortality in cancer survivors, particularly in those having undergone mediastinal radiation. While mediastinal radiation has been shown to substantially reduce both recurrence and mortality rates in multiple thoracic malignancies, the risk for the development of RICHD is of significant concern.
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