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Surgical resection of a solitary fibrous tumour causing refractory hypoglycaemia: Doege-Potter syndrome.
BMJ Case Rep
January 2025
Department of Surgery, Sinai Grace Hospital, Detroit Medical Center, Detroit, Michigan, USA.
Solitary fibrous tumours (SFTs) are rare soft tissue masses that are often clinically silent until they cause mass effect. A paraneoplastic syndrome manifesting as persistent hypoglycaemia, termed Doege-Potter syndrome (DPS), can be associated with these lesions. Surgical treatment is recommended for the management of these tumours.
View Article and Find Full Text PDFClinical pathology and molecular examination of Babesia spp. infection in dogs; Mashhad, Northeast Iran.
Microb Pathog
November 2024
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Iran. Electronic address:
Article Synopsis
- This study investigated Babesia infection in dogs in Mashhad, Iran, focusing on its prevalence and comparing clinical, hematological, and clinicopathological differences between infected and non-infected dogs.
- The researchers analyzed blood samples from 150 dogs, including owned, stray, and shelter dogs, using microscopy and PCR, finding a higher prevalence via PCR (15.3%) than microscopy (2%).
- Key findings showed that housing status and age significantly affected infection rates, with infected dogs exhibiting substantially lower hematocrit and RBC counts, alongside severe anemia and other clinical abnormalities in some cases.
The correlation of asparaginase enzyme activity levels after PEG-asparaginase administration with clinical characteristics and adverse effects in Chinese paediatric patients with acute lymphoblastic leukaemia.
Br J Haematol
August 2024
Department of Pediatric Hematology, Fujian Medical University, Union Hospital, Fuzhou, China.
Studies on asparaginase enzyme activity (AEA) monitoring in Chinese patients receiving PEG-asparaginase remain limited. We monitored AEA in paediatric patients diagnosed with acute lymphoblastic leukaemia (ALL) and treated according to the Chinese Children's Cancer Group study protocols, CCCG-ALL-2015/CCCG-ALL-2020 protocols. We measured the AEA at days 7 ± 1 and 14 ± 1 and analysed their association with patient characteristics and PEG-asparaginase-related adverse effects (AEs).
View Article and Find Full Text PDFAffordable oral proinsulin bioencapsulated in plant cells regulates blood sugar levels similar to natural insulin.
Biomaterials
July 2023
Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Diabetes Mellitus is a growing global health crisis, impacting over 500 million people with an alarming increase in cases among those under 20 and high mortality rates, while insulin accessibility remains a significant issue worldwide.
- Researchers developed a method for oral delivery of engineered proinsulin using plant cells, achieving stable expression and meeting FDA standards, thus potentially making treatment more accessible and cost-effective.
- The study demonstrated that oral proinsulin effectively regulates blood sugar levels in mice similarly to natural insulin, presenting a viable alternative to traditional insulin injections and paving the way for potential clinical applications.
Should continuous glucose monitoring be used to manage neonates at risk of hypoglycaemia?
Front Pediatr
March 2023
School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
The National Institute for Clinical Excellence (NICE) now recommends that continuous glucose monitoring (CGM) be offered to adults and children with diabetes who are at risk from hypoglycaemia. Hypoglycaemia is common in the neonatal period, and is a preventable cause of poor neurodevelopmental outcome, but is CGM helpful in the management of neonates at risk of hypoglycaemia? Neonatal studies have shown that CGM can detect clinically silent hypoglycaemia, which has been associated with reduced executive and visual function in early childhood. Intervention trials have further shown CGM can support the targeting of glucose levels in high-risk extremely preterm neonates.
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