AI Article Synopsis
- A microfabricated device allows for the controlled release of two drugs, edaravone (EDV) and unoprostone (UNO), designed for simultaneous delivery to the retina.
- This combined approach enhances retinal protection against light damage in rat models more effectively than using each drug separately.
- The device presents a potentially safer alternative to traditional intravitreal injections for treating retinal diseases.
Article Abstract
Controlled transscleral co-delivery of two drugs, edaravone (EDV) and unoprostone (UNO), using a platform that comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which are made of photopolymerized poly(ethyleneglycol) dimethacrylates, shows synergistic retinal neuroprotection against light injury in rats when compared with single-drug-loaded devices. The device would offer a safer therapeutic method than intravitreal injections for retinal disease treatments.
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| http://dx.doi.org/10.1002/adhm.201400114 | DOI Listing |
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