Ventricular ectopic beats (VEBs) are often encountered in daily clinical practice. Clinical significance of VEBs seen in patients without structural cardiovascular diseases is controversial. We aimed to investigate the effects of VEBs on left atrium (LA) function using speckle tracking echocardiography with LA strain parameters. Patients with frequent VEBs (more than 30 times in 1 h, according to the Lown classification) were identified. Identified patients were evaluated by speckle tracking methods. There were 40 patients with frequent VEBs and 40 controls in our study. The general characteristics were similar of the study population. The LA global longitudinal strain parameters were significantly different. Global Peak atrial longitudinal strain (PALS) (38.39 ± 7.93 vs. 44.15 ± 6.71, p = 0.001) and peak atrial contraction strain (PACS) (16.37 ± 4.58 vs. 20.49 ± 3.65, p = 0.000) were revealed significantly lower in the VEBs group. Time to peak longitudinal strain (TPLS) was found significantly longer in the VEBs group [485.5 (352-641) vs. 435 (339-516.5) p = 0.000]. Number of VEBS was correlated with TPLS (r = 0.499, p = 0.000). PALS and PACS were negatively correlated with number of VEBs (r = -0.348, p = 0.002 and r = -0.444, p = 0.000, respectively). We described that in this study, The LA functions are affected by VEBs adversely. This deterioration is increasing as the number of VEBs.
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Sci Rep
December 2024
School of Civil Engineering, Shangqiu Lnstitute of Technology, Shangqiu, 476000, China.
Electroosmosis and surcharge preloading represent two effective soil consolidation methodologies. Their combined application has been proven to be effective in shortening the consolidation period and mitigating the degradation of electroosmotic consolidation performance due to crack generation. In this study, an axisymmetric free-strain consolidation analytical model incorporating a continuous drainage top boundary was established.
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December 2024
College of Energy Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China.
Affected by weakening effect of water in the goaf, the bearing capacity of coal pillar reduced, and coal pillar rock burst is prone to occur, which is a serious threat to mine safety in production. In order to study the equivalent width and stability of coal pillar in water-rich coal seam, taking the section coal pillar of a working face as the research object, combined with laboratory test, theoretical analysis, simulation and engineering practice, the stress, elastic core area width, damage degree and energy accumulation of 36 m water-immersed coal pillar and 26 m, 28 m, 30 m, 32 m, 36 m unimmersed coal pillars are analyzed. The research results show that: (1) The reasonable width of coal pillar under flooded and unflooded conditions is 36.
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December 2024
Department of Microbiology and Immunology, Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
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View Article and Find Full Text PDFJ Biomol Struct Dyn
December 2024
Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, India.
In the relentless pursuit of unraveling the intricate pathophysiology of Alzheimer's disease (AD), amyloid β (Aβ) proteins emerge as focal points due to their pivotal role in disease progression. The pathological hallmark of AD involves the aberrant aggregation of Aβ peptides into amyloid fibrils, precipitating a cascade of neurodegenerative events culminating in cognitive decline and neuronal loss. This study adopts a computational framework to investigate the potential therapeutic efficacy of novel biosurfactants (BS) in mitigating Aβ fibril formation.
View Article and Find Full Text PDFJ Echocardiogr
December 2024
Department of Cardiology, Lebanese American University Medical Center - Rizk Hospital, Beirut, Lebanon.
Left atrial strain (LAS) was recently introduced as a parameter that reflects on left atrial function. Consequently, changes in LAS can inform the development of cardiovascular diseases, hence providing a window for non-invasive and cost-effective testing of these diseases and their complications at early stages of development, potentially offering a segway towards preventive interventions. LAS has yet to be implemented into standard practice.
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