IgG/IgA pemphigus has recently been described in the literature as an overlap of pemphigus vulgaris or pemphigus foliaceus with IgA pemphigus. There has also been some postulation that this IgG/IgA pemphigus may be associated with internal malignancy as well. Our case demonstrates the unique clinical, histopathological, and direct immunofluorescence findings of IgG/IgA pemphigus and further highlights the possibility of association of this disease with internal malignancy.
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http://dx.doi.org/10.1097/DAD.0000000000000058 | DOI Listing |
Int J Dermatol
January 2025
Dermatology Department, Hospital Universitario 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Ann Diagn Pathol
December 2024
Tekirdağ Namık Kemal University Medical Faculty, Dermatology and Venereology Department, Tekirdağ, Turkey. Electronic address:
Indian J Pathol Microbiol
April 2024
Department of Dermatology, Maulana Azad Medical College, New Delhi, Delhi, India.
Biomolecules
April 2023
Department of Laboratory Medicine, Medical College, Dalian University, Dalian 116622, China.
Autoimmune bullous diseases (AIBDs), which are a group of tissue-specific autoimmune diseases of the skin, present with various blistering lesions on the skin and mucous membranes, and show autoantibodies of IgG, IgA and IgM against epidermal cell surfaces and basement membrane zone. To date, AIBDs have been classified into a number of distinct subtypes by clinical and histopathological findings, and immunological characteristics. In addition, various biochemical and molecular biological studies have identified various novel autoantigens in AIBDs, which has resulted in proposals of new subtypes of AIBDs.
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