AI Article Synopsis
- The study developed organogel nanoparticles for use in cosmetics and drug delivery systems, focusing on their preparation and characterization.
- Methods included creating gelled particles using hot emulsification, incorporating a UVB sunscreen model, and evaluating various physicochemical properties such as stability, particle size, and UVB absorption.
- Results indicated that the nanoparticles had optimal size and stability, significantly enhancing the UVB protection and resistance to water immersion, making them promising for future applications.
Article Abstract
Objective: The preparation and physicochemical characterization of organogel nanoparticles dispersed in water have been developed. These systems could be employed as nanocarrier for cosmetic applications or as hydrophobic reservoirs for drug delivery.
Methods: Gelled particles of organic liquid and 12-hydroxystearic acid (organogelator) were obtained by hot emulsification (T>Tgel), with a surfactant (acetylated glycol stearate) and polymers (sodium hyaluronate and polyvinyl alcohol) as stabilizing agents, and cooling at room temperature (T
Results: According to the gelation test results, organogels were obtained with various organic liquids. Vaseline and almond oils were selected as organic medium for the gelled nanoparticle preparation. A preliminary formulation study was carried out in order to determine the optimal experimental conditions to obtain stable nanoparticle dispersions. Gelled nanoparticles contained the sunscreen model molecule, with mean size of 450 nm, polydispersity index of 0.18 and zeta-potential value above -30 mV, were obtained by ultrasound probe homogenization method. A comparative study of their dispersion ageing showed a greatly enhanced stability after gelation. According to the UVB absorption evaluation, gelled particles improved the photoprotective ability and the photostability of immobilized UVB blocker. They showed a high water resistance (~83%) even after 40 min of immersion.
Conclusion: The obtained results demonstrate the interest of these gelled nanoparticles and their aqueous dispersion for the preparation of new formulations for cosmetic and dermo-cosmetic applications.
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