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| http://dx.doi.org/10.2319/0003-3219-84.3.568 | DOI Listing |
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elements are primate-specific retrotransposon sequences that comprise ∼11% of human genomic DNA. sequences contain an internal RNA polymerase III promoter and the resultant RNA transcripts mobilize by a replicative process termed retrotransposition. retrotransposition requires the Long INterspersed Element-1 (LINE-1) open reading frame 2-encoded protein (ORF2p).
View Article and Find Full Text PDFAn Open-Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second-Line Therapy for Advanced Head and Neck Squamous Cell Cancers.
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Medical Oncology Healthcare Global Bangalore India.
Background And Aims: Sensitivity to immune checkpoint inhibitor (ICI) therapy depends in part on the genetic and epigenetic makeup of cancer cells, and CD8 T-lymphocytes that mediate immune responses. Epigenetics are heritable reversible changes in gene expression that occur without any changes in the nuclear DNA sequence or DNA copy number.
Primary Objective: i.
Numerical Modelling of Hybrid Polymer Composite Frame for Selected Construction Parts and Experimental Validation of Mechanical Properties.
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Department of Material Science and Manufacturing Technology, Faculty of Engineering, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague, Czech Republic.
This article is a numerical and experimental study of the mechanical properties of different glass, flax and hybrid composites. By utilizing hybrid composites consisting of natural fibers, the aim is to eventually reduce the percentage usage of synthetic or man-made fibers in composites and obtain similar levels of mechanical properties that are offered by composites using synthetic fibers. This in turn would lead to greener composites being utilized.
View Article and Find Full Text PDFThe Role of Immersive Experience in Anxiety Reduction: Evidence from Virtual Reality Sessions.
Brain Sci
December 2024
Department of Psychology and Developmental Psychopathology, University of Gdansk, 80-309 Gdańsk, Poland.
Background/objectives: Virtual reality (VR) is an innovative technology with the potential to transform digital experiences, particularly in relation to mental health concerns such as anxiety. Therefore, this study investigates the potential of a newly designed VR experience to alleviate anxiety by focusing on the mediating role of VR-induced immersion.
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ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case.
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Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
A case of cutaneous adnexal neoplasm with unusual squamoid morphology and harboring an in frame ACTB::ZMIZ2 fusion transcript was recently described. Herein, we report a second case of adnexal carcinoma harboring similar morphology and an identical in frame ACTB::ZMIZ2 fusion transcript. This 2.
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