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Three-Year Outcomes With a Supra-Annular, Self-Expanding Bioprosthesis and a Pericardial Wrap-The FORWARD PRO Study.
Catheter Cardiovasc Interv
December 2024
Center of Innovative Interventions in Cardiology, University Hospital Bonn, Bonn, Germany.
Background: The self-expanding, supra-annular Evolut valve is an established platform for Transcatheter Aortic Valve Implantation (TAVI). Evolut PRO introduced an outer sealing wrap to mitigate paravalvular leakage. We evaluated the 3-year clinical outcomes and valve performance of the Evolut PRO in standard clinical practice for severe aortic stenosis (AS) patients at intermediate or higher risk for surgery.
View Article and Find Full Text PDFNovel retrieving device for coronary stent dislodgement.
BMC Cardiovasc Disord
November 2024
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Article Synopsis
- Stent dislodgement is a rare but difficult complication during heart procedures, and existing treatment methods are not very effective.
- This study tested a new self-expanding basket (SEB) catheter designed to retrieve dislodged stents without causing additional injury or needing surgery.
- In a small trial with 6 patients, the SEB catheter successfully retrieved all dislodged stents, with no safety issues reported, indicating it may be a promising solution, but more extensive research is needed.
Teaching pediatric cardiology fellows to communicate serious news: a pilot study.
BMC Med Educ
October 2024
Department of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.
Article Synopsis
- Pediatric cardiology fellows often need to communicate serious news to families and effective communication is vital for building relationships and improving health outcomes.
- A 3-hour training session using VitalTalk methodology focused on teaching fellows how to deliver difficult news and handle emotional responses, including role play with actors to practice skills.
- After the training, all 9 participating fellows reported enhanced preparedness and comfort in discussing challenging topics related to pediatric cardiology, such as new congenital heart disease diagnoses and poor prognoses.
Type a aortic dissection after aortic wrapping performed 26 years ago: a case report.
J Cardiothorac Surg
October 2024
Department of Cardiovascular Surgery, Kansai Rosai Hospital, 3-1-69, Amagasaki, 660-8511, Amagasaki, Japan.
Background: Aortic wrapping (AW) has been performed as a less invasive alternative to aortoplasty. However, AW can also cause long-term aortic complications. In this report, we present a rare case of a dissecting aortic aneurysm between the proximal side of the wrap and the sinotubular junction after AW.
View Article and Find Full Text PDFSelective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple Myeloma.
Cancer Res
December 2024
Dana-Farber Cancer Institute, Boston, Massachusetts.
MYC deregulation occurs in the majority of multiple myeloma cases and is associated with progression and worse prognosis. Enhanced MYC expression occurs in about 70% of patients with multiple myeloma, but it is known to be driven by translocation or amplification events in only ∼40% of myelomas. Here, we used CRISPR interference to uncover an epigenetic mechanism of MYC regulation whereby increased accessibility of a plasma cell-type-specific enhancer leads to increased MYC expression.
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