AI Article Synopsis
- Researchers conducted a room temperature electron magnetic resonance (EMR) study on l-threonine, an amino acid, to identify stable radicals formed by X-ray irradiation.
- The radicals analyzed share structural similarities with l-alanine, a known dosimetric material, allowing for direct comparison of radiation-induced defects between the two substances.
- The study identified three different radicals, two of which have similar structures but differ in their conformation, while the third radical likely results from deamination and resembles the stable radical found in alanine.
Article Abstract
In the past, decennia radiation-induced radicals were successfully identified by electron magnetic resonance (EMR) in several solid-state amino acids and sugars. The authors present a room temperature (RT) EMR study of the stable radicals produced by X-ray-irradiation in the amino acid l-threonine (CH₃CH(OH)CH(NH₃ (+))COO(-)). Its chemical structure is similar to that of the well-known dosimetric material l-alanine (CH₃CH(NH₃(+))COO(-)), and radiation defects in l-threonine may straightforwardly be compared with the extensively studied l-alanine radicals. The hyperfine coupling tensors of three different radicals were determined at RT using electron nuclear double resonance. These results indicate that the two most abundant radicals share the same basic structure CH₃(•)C(OH)CH(NH₃(+))COO(-), obtained by H-abstraction, but are stabilised in slightly different conformations. The third radical is most probably obtained by deamination (CH₃CH(OH)(•)CHCOO(-)), similar in structure to the stable alanine radical.
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| http://dx.doi.org/10.1093/rpd/ncu123 | DOI Listing |
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