The development of lentigines in areas previously involved by psoriasis has been reported in the literature, classically related to phototherapy but also to topical products. More recently, some authors have described several cases of lentigines appearing in resolving psoriatic plaques during or after treatment with anti-tumour necrosis factor (TNF) drugs used to treat severe plaque psoriasis, including adalimumab, etanercept, and infliximab. We report the case of a patient that developed multiple lentigines after clearance of the plaques of psoriasis receiving treatment with ustekinumab for his psoriasis.
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Genomic ascertainment to quantify prevalence and cancer risk in adults with pathogenic and likely pathogenic germline variants in RASopathy genes.
medRxiv
October 2024
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA.
Purpose: Genomic ascertainment of electronic health record-linked exome data in two large biobanks was used to quantify germline pathogenic/likely pathogenic (P/LP) variant prevalence, cancer prevalence, and survival in adults with non- RAS/mitogen-activated protein kinase genes (RASopathies).
Patients And Methods: Germline RASopathy variants were examined from adult participants in UK Biobank (UKBB; n=469,802), Geisinger MyCode (n=167,050) and Mount Sinai Bio (n=30,470). Variants were classified as per American College of Medical Genetics/Association for Molecular Pathology criteria and reviewed by a RASopathy variant expert.
Deferred Lateral Margin Control in the Surgical Treatment of Genital Paget's Disease and Lentiginous Vulvar Melanoma.
J Clin Med
December 2024
Department of Dermatology, University Clinic of Navarra, 28027 Madrid, Spain.
Some skin tumors can extend beyond their clinical appearance. This presents an additional challenge, especially when the affected area is the genital region, which is more difficult for both the patient and the physician to access and monitor due to its location and anatomical characteristics. The treatment of these lesions is complex, and literature postulates Mohs surgery as the best therapeutic option.
View Article and Find Full Text PDF[Current research status of Peutz-Jeghers syndrome in children].
Zhongguo Dang Dai Er Ke Za Zhi
October 2024
Department of Digestive Nutrition, Hunan Children's Hospital, Changsha 410007, China.
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Combined programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 blockade in an international cohort of patients with acral lentiginous melanoma.
Br J Dermatol
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Department of Medicine, USC Keck School of Medicine, Los Angeles, CA, USA.
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An uncommon case of anorectal malignant melanoma (ARMM): Clinical presentation and surgical outcome.
Int J Surg Case Rep
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Department of Surgery, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
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