Universal area distributions in the monolayers of confluent mammalian cells.

Phys Rev Lett

Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA and Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

Published: April 2014

When mammalian cells form confluent monolayers completely filling a plane, these apparently random "tilings" show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the "newborn" ones--remarkably, the modeled and experimental distributions fit well when all free parameters are estimated directly from experiments.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113185PMC
http://dx.doi.org/10.1103/PhysRevLett.112.138104DOI Listing

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