The investigation revealed the specific features of cell-mediated hepatocyte damage in different variants of the natural course of chronic HBV and HCV infection and in its outcomes (chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma), by determining the expression of proapoptotic (Fas, FasL) and antiapoptotic (bcl-2) factors on the surface of intralobular lymphocytes. Comparative analysis of the magnitude and pattern of cell infiltration in the liver parenchyma, the functional activity of intralobular lymphocytes showed significant differences in the above indicators in relation to the etiology and stage of the pathological process, suggesting that there were different pathogenetic mechanisms of their natural course. There was a varying potential readiness of intralobular lymphocytes for apoptosis, giving rise to different clinical manifestations in the similar morphological picture.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Barriers and facilitators to healthy eating among college students.
Nutr Res
June 2024
Department of Food Science and Human Nutrition, G.M. Trout FSHN Building, College of Agriculture & Natural Resources, Michigan State University, East Lansing, MI, USA.
Young adulthood is an influential life stage for developing lifelong eating patterns, yet limited research characterizes dietary intake among young adults. This cross-sectional study assessed dietary intake and characteristics associated with nutrition knowledge and healthy food consumption among college students. We hypothesized that healthy food intake would be lower than United States (U.
View Article and Find Full Text PDFBirth weight and prepubertal growth trajectory had a combined effect on pubertal initiation in girls.
Acta Paediatr
January 2025
Centre for Adolescent Health, Murdoch Children's Research Institute and Royal Children's Hospital, Parkville, Victoria, Australia.
Aim: Most studies of prepubertal weight and puberty have not used continuous or long follow-up periods. We explored the effect that birth weight and growth trajectories from 0-9 years of age had on starting puberty.
Methods: Data were obtained from 1510 children in Tianjin, China, who were born in 2013 and selected by cluster random sampling.
Circadian entrainment and external cues can cause gene transcript abundance to oscillate throughout the day, and these patterns of diel transcript oscillation vary across genes and plant species. Less is known about within-species allelic variation for diel patterns of transcript oscillation, or about how regulatory sequence variation influences diel transcription patterns. In this study, we evaluated diel transcript abundance for 24 diverse maize inbred lines.
View Article and Find Full Text PDFDynamics of the prognostic index during the course of treatment for anaplastic thyroid carcinoma.
Surg Today
January 2025
Department of Endocrine Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.
Purpose: Tumor/node/metastasis staging and prognostic index (PI) are used to predict prognosis and guide treatment for anaplastic thyroid carcinoma (ATC). With the advent of treatments, such as BRAF/MEK inhibitors and immune checkpoint inhibitors, dynamic markers to assess disease status and treatment efficacy are needed. This study examined the utility of PI as a dynamic marker for ATC treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!