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| http://dx.doi.org/10.5505/tjh.2012.52296 | DOI Listing |
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Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
Clin Pharmacol Ther
November 2019
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and Southern European CBZ-SCAR cases and 10,701 population controls and a GWAS on 12 CBZ-DILI cases and 8,438 ethnically matched population controls. HLA-A*31:01 was identified as the strongest genetic predisposing factor for both CBZ-SCAR (odds ratio (OR) = 8.
View Article and Find Full Text PDFCarbamazepine-induced Red Blood Cell Aplasia: A Case Report.
Turk J Haematol
June 2012
Gata Haydarpaşa Teaching Hospital, Department of Pediatrics, Uskudar, Istanbul, Turkey.
Interferon-alpha is a predisposing risk factor for carbamazepine-induced hyponatremia: A case of syndrome of inappropriate antidiuresis caused by interferon-alpha therapy.
Int J Gen Med
November 2008
Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan.
A 31-year-old man had been treated with carbamazepine (CBZ) for 6 years and warfarin with bucolome for 2 years before developing hyponatremia 7 days after an injection of interferon-alpha 2b and starting oral ribavirin for chronic hepatitis C virus infection. Despite the hyponatremia, urinary osmolality exceeded plasma osmolality, and urinary excretion volume decreased markedly after water loading. Restriction of water intake and administration of dimethylchlortetracycline improved the hyponatremia, and lithium therapy maintained the normonatremia for one year.
View Article and Find Full Text PDFCarbamazepine-induced hemolytic and aplastic crises associated with reduced glutathione peroxidase activity of erythrocytes.
Int J Hematol
November 2007
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan.
Although pure red cell aplasia is a well-known side effect of carbamazepine treatment, intravascular hemolytic anemia is rare. We describe a 5-year-old boy who developed concurrent intravascular hemolytic anemia and erythroblastopenia, probably due to carbamazepine. Carbamazepine treatment was subsequently discontinued, and the patient was treated with red blood cell transfusions, haptoglobin, and methylprednisolone.
View Article and Find Full Text PDFCarbamazepine-induced IgG1 and IgG2 deficiency associated with B cell maturation defect.
Seizure
April 2004
Department of Pediatrics, Takatsuki Red Cross Hospital, Takatsuki, Osaka, Japan.
This paper presents the first case of asymptomatic IgG1 and IgG2 deficiency induced by carbamazepine (CBZ). The patient has remained asymptomatic since CBZ was started because IgM reduced only transiently, IgA decreased but remained within the normal range, and the specific antibodies to organisms having capsular polysaccharide antigens were not defective in this case. Analysis of membrane surface immunoglobulin (sIg) on B lymphocytes indicated that the maturation of B cells was defective from sIgM+ cells to sIgG+ cells.
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