Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.

World J Gastroenterol

Abhishek Choudhary, Jessica Winn, Sameer Siddique, Murtaza Arif, Zainab Arif, Ghassan M Hammoud, Jamal A Ibdah, Matthew L Bechtold, Division of Gastroenterology, Department of Internal Medicine, University of Missouri-Columbia, M580 Health Sciences Center, Columbia, MO 65212, United States.

Published: April 2014

Aim: To conduct a systemic review and meta-analysis to investigate the role of early precut technique. Multiple randomized controlled trails (RCTs) have reported conflicting results of the early precut sphincterotomy.

Methods: MEDLINE/PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Database of Systematic Reviews, and recent abstracts from major conference proceedings were searched (June 2013). Randomized and non-randomized studies comparing early precut technique with prolonged standard methods were included. Pooled estimates of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP), cannulation and adverse events were analyzed by using odds ratio (OR). Random and fixed effects models were used as appropriate. Publication bias was assessed by funnel plots. Heterogeneity among studies was assessed by calculating I² measure of inconsistency.

Results: Seven randomized and seven non-randomized trials met inclusion criteria. Meta-analysis of RCTs showed a decrease trend for PEP with early precut sphincterotomy but was not statistically significant (OR = 0.58; 95%CI: 0.32-1.05; P = 0.07). No heterogeneity was noted among the studies with I² of 0%.

Conclusion: Early precut technique for common bile duct cannulation decreases the trend of post-ERCP pancreatitis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983468PMC
http://dx.doi.org/10.3748/wjg.v20.i14.4093DOI Listing

Publication Analysis

Top Keywords

early precut
20
precut technique
12
precut sphincterotomy
8
post-endoscopic retrograde
8
retrograde cholangiopancreatography
8
review meta-analysis
8
randomized non-randomized
8
heterogeneity studies
8
precut
6
early
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!