Induced by microbial intervention oxidative stress causes electronic transport disorder in gingival cells mitochondrias as well as decrease of energogenesis and increase of lipoperoxidation. In oral cavity local immunity is decreased in parodontitis, that is related with immunoglobulin A deficiency and lysozyme activity decrease. Against this background, microbial factors damaging effect on periodont is intensified. In parodontitis the free nitric oxide (NO) content decrease in gingival tissues and its appearance in saliva is related with transformation of NO into toxic peroxinitrite, that on its turn enhances oxidation, parodontal injury, cell degra dation and necrosis. Nitrooxide defficiency in gingival mucosal cells is characterized by decreased protein P-53 expression and terminal differentiation disorder of the cells. Mitochodria related energogenesis disorder in gums causes inhibition of their cell regeneration, which together with apoptotic changes is characterized with parodontal tissue destruction and depletion.
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ASSESSMENT OF LASER AND ANTIOXIDANT THERAPY EFFICACY IN TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS.
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1Saint Petersburg State University, Department of Clinical Dentistry SPbU; Russian Federation.
Chronic generalized parodontitis is one of the most prevalent disorders among diseases of oral cavity, making the search for optimal treatment modalities of this disorder one of the mostressing matters to this day. The purpose of this study was to assess outcomes of conventional therapy and secondary prevention of chronic generalized parodontitis with in combination with use of laser therapy and antioxidant drug treatment. The study is presented as a joint multi-site investigation conducted by the group of authors from St.
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Georgian Med News
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Bogomolets National Medical University, Institute Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.
Generalized parodontal diseases (GPD) consistently occupy one of the leading places in the structure of dental diseases. Early diagnosis of the initial degree of generalized parodontitis (GP) is an effective way of secondary prevention. This is due to the complexity of understanding the etio-pathogenetic mechanisms of the development generalized parodontal diseases (GPD) and the high association of them with a number of diseases of the internal organs and systems with common points of contact between interdependence and mutual influence, in particular with anorexia nervosa (AN).
View Article and Find Full Text PDF[Parodontitis pathogenetic factors, their interaction and effects].
Georgian Med News
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Tbilisi State Medical University, Georgia.
Induced by microbial intervention oxidative stress causes electronic transport disorder in gingival cells mitochondrias as well as decrease of energogenesis and increase of lipoperoxidation. In oral cavity local immunity is decreased in parodontitis, that is related with immunoglobulin A deficiency and lysozyme activity decrease. Against this background, microbial factors damaging effect on periodont is intensified.
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