Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Novel rhodanine-thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach.
RSC Med Chem
November 2024
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research Mysuru-570015 Karnataka India.
New rhodanine-thiazole clubbed compounds (7a-7l) were synthesised and characterised with various spectroscopy methods. The synthesised hybrids underwent HPA, HLAG inhibition, and peroxisome proliferator-activated receptor-gamma (PPAR-γ) expression assays. Through the biological study, compound 7f showed promising inhibitory activity against HPA with an IC value of 27.
View Article and Find Full Text PDFDigital clubbing without hypoxia for lysinuric protein intolerance.
Eur J Med Genet
October 2024
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan. Electronic address:
Digital clubbing is characterized by bulbous enlargement of the terminal segments of the fingers. Hypotheses including hypoxia have been proposed for the pathogenesis of digital clubbing, but the exact pathogenesis of digital clubbing is still uncertain. Lysinuric protein intolerance (LPI) is caused by pathogenic variants in SLC7A7 and is often associated with interstitial lung disease.
View Article and Find Full Text PDFArticle Synopsis
- A 39-year-old woman with a history of systemic lupus erythematosus (SLE) and antiphospholipid syndrome experienced ongoing symptoms including fever and joint pain.
- She was admitted to the ER due to sudden difficulty breathing and discovered to have clubbed fingers, which started 5 months earlier; imaging showed severe mitral valve damage with a large mass.
- Despite initial treatment for suspected infectious endocarditis and subsequent surgeries, the mass was ultimately diagnosed as high-grade sarcoma, underscoring the need for careful interdisciplinary management in unusual medical cases.
Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis.
Front Chem
April 2024
Department of Chemistry and Manchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.
Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly -glucosidase, could serve as an effective methodology in treating diabetes. Attributed to the catalytic function of glucosidase, the present research focuses on the synthesis of sulfonamide-based acyl pyrazoles followed by their and screening against -glucosidase.
View Article and Find Full Text PDFAn insight on medicinal attributes of 1,2,3- and 1,2,4-triazole derivatives as alpha-amylase and alpha-glucosidase inhibitors.
Mol Divers
October 2024
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
Article Synopsis
- Diabetes Mellitus (DM) is a widespread metabolic disorder characterized by high blood sugar levels due to insufficient insulin secretion, often caused by excessive glucose consumption.
- Enzymes like α-amylase and α-glucosidase are key players in carbohydrate metabolism, and targeting their inhibition represents a promising strategy for developing new antidiabetic medications.
- The review highlights various triazole-based compounds and their molecular hybrids that have shown potential in inhibiting the aforementioned enzymes, discussing their structure-activity relationships, enzyme inhibitory activities, and related patents to facilitate future therapeutic advancements.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!