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Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. | LitMetric

Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease.

J Immunol Res

Cardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.

Published: January 2015

AI Article Synopsis

  • The rise in obesity rates has led to a sharp increase in obesity-related health issues, fueled by excess energy intake and the expansion of adipose (fat) tissue.
  • As fat tissue grows, it triggers inflammation through the release of lipids and various signaling molecules, linking obesity to serious health problems like insulin resistance and metabolic syndrome.
  • This review highlights specific chemokines that play a significant role in the progression of obesity and its associated complications.

Article Abstract

The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. This low-grade chronic inflammation is thought to link obesity to insulin resistance and the associated comorbidities of metabolic syndrome such as dyslipidemia and hypertension, which increase risk of type 2 diabetes and cardiovascular disease. In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987870PMC
http://dx.doi.org/10.1155/2014/181450DOI Listing

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