Objective: To study the effect of octreotide therapy on endometriotic lesions in a patient with coexisting endometriosis and acromegaly.
Intervention Patient: A 34-year-old female was diagnosed with acromegaly and coexisting endometriosis. Post-surgical resection of the tumor, patient was initiated on octreotide therapy.
Results: There was improvement in menstrual bleeding as IGF1 levels decreased with Octreotide therapy. Resolution of the endometriotic lesions was observed during follow up.
Conclusion: In this unusual case, the treatment of acromegaly concurred with regression in the endometriotic lesions. Causal or incidental association cannot be inferred from the present case.
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http://dx.doi.org/10.4103/2230-8210.129122 | DOI Listing |
Am J Transl Res
December 2024
Department of Gastrointestinal Surgery, Suzhou Ninth People's Hospital Suzhou 215200, Jiangsu, China.
The diagnosis and treatment of intestinal and urinary tract deep infiltrating endometriosis (DIE) remain challenging due to its multiple lesions and nonspecific symptoms and signs. This study retrospectively analyzed 72 cases of intestinal and urinary tract DIE, including the clinical characteristics, diagnosis, and treatment outcomes. Among these cases, 11 presented without clinical symptoms, while 61 exhibited obvious clinical symptoms, primarily dysmenorrhea (58.
View Article and Find Full Text PDFNarra J
December 2024
Doctoral Program of Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.
Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, is recognized for its pharmacological effects, which might be beneficial in managing endometriosis. The aim of the study was to investigate the pharmacological effects of as a potential therapy for endometriosis by using an animal model.
View Article and Find Full Text PDFCephalalgia
January 2025
Department of Pharmacology, University of Arizona College of Medicine, Tucson, AZ, USA.
Background: Women with endometriosis are more likely to have migraine. The mechanisms underlying this co-morbidity are unknown. Prolactin, a neurohormone secreted and released into circulation from the anterior pituitary, can sensitize sensory neurons from female, but not male, rodents, monkeys and human donors.
View Article and Find Full Text PDFEndometriosis, though not classified as a carcinogenic condition, shares features such as oxidative stress, migration, invasion, angiogenesis, and inflammation with tumor cells. This study aims to review the effects of flavonoids on these processes and their molecular mechanisms in preventing and treating endometriosis. A comprehensive review was conducted, involving a literature search in online databases using keywords like "endometriosis," "endometrioma," and "flavonoid.
View Article and Find Full Text PDFJ Ethnopharmacol
January 2025
The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, China. Electronic address:
Ethnopharmacological Relevance: The rhizome of Curcuma phaeocaulis Valeton, Curcuma wenyujin Y.H. Chen & C.
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