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| http://dx.doi.org/10.4103/0976-3147.127938 | DOI Listing |
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A mitochondrial targeted fluorescent probe for imaging nitroreductase activity and photodynamic therapy in tumor cells.
Talanta
December 2024
Department of Hepato-Pancreato-Biliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315211, China; Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China. Electronic address:
The hypoxic environment in tumors is closely linked to tumor structure, function, dissemination, invasion, metastasis, and drug resistance. Nitroreductase (NTR) is often recognized as a biomarker to evaluate the hypoxia degree for tumor cells. Traditional detection methods such as PET, MRI and multispectral photoacoustic tomography have limitations.
View Article and Find Full Text PDFDiagnostic Accuracy and Value of CXCR4-targeted PET/MRI Using Ga-Pentixafor for Tumor Localization in Cushing Disease.
Radiology
December 2024
From the Department of Radiology (Yue Wu, S.W., W.R., Z. Yao), Department of Neurosurgery, Shanghai Pituitary Tumor Center (B.Y., Z. Ye, R.H., N.Q., Y. Zhang, X.Y., Z.M., Y. Wang, Y. Zhao, Q.Z.), Department of Nuclear Medicine and PET Center (Yanfei Wu, S.R., Y.G., F.X.), and Department of Endocrinology (M.H., S.Z., Y.Y., H.Y., Z.Z.), Huashan Hospital, Fudan University, 12 Wulumuqi Road, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai, China (B.Y., Z. Ye, R.H., N.Q., Y. Zhang, X.Y., Z.M., Y. Wang, Y. Zhao, Q.Z.); Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China (B.Y., Z. Ye, R.H., N.Q., Y. Zhang, X.Y., Z.M., Y. Wang, Y. Zhao, Q.Z.); Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China (B.Y., Z. Ye, R.H., N.Q., Y. Zhang, X.Y., Z.M., Y. Wang, Y. Zhao, Q.Z.); and Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Neuroendocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Mass (Q.Z.).
Background Gallium 68 (Ga) pentixafor has emerged as a potential C-X-C chemokine receptor type 4 (CXCR4)-targeted radiotracer for neuroendocrine tumor, yet its application in Cushing disease remains uncertain. Purpose To assess the diagnostic accuracy and value of Ga-pentixafor PET/MRI in localizing adrenocorticotropic hormone (ACTH)-secreting pituitary tumors in Cushing disease. Materials and Methods A prospective single-center study was conducted from March 2023 to February 2024 in participants with Cushing disease scheduled for surgical pituitary tumor resection.
View Article and Find Full Text PDFPreoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [Ga]Ga-PSMA-11 PET/MRI.
Insights Imaging
December 2024
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
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- Radical prostatectomy (RP) is a standard treatment for localized prostate cancer, but accurately detecting extraprostatic extension (EPE) before surgery is difficult, which can lead to suboptimal treatments.
- This study explores using explainable machine learning to improve EPE detection by analyzing data from newly diagnosed prostate cancer patients who underwent PET/MRI imaging and subsequent surgery.
- The results showed machine learning models outperformed traditional imaging methods in predicting EPE, which could lead to better clinical decision-making and improved patient outcomes.
Application of rare earth elements in dual-modality molecular probes.
RSC Adv
December 2024
School of Food and Drug, Shenzhen Polytechnic University Shenzhen 518055 China
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- - The 4f subshell electronic structure of rare earth elements gives them unique electrical, magnetic, and optical properties, making them suitable for creating molecular probes with features like long fluorescence lifetimes and strong resistance to photobleaching.
- - Different imaging techniques offer distinct benefits but also come with limitations, and dual-modality molecular probes help overcome these issues, particularly in advanced Magnetic Resonance Imaging (MRI) applications.
- - This review explores the uses, advantages, challenges, and current state of research on rare earth elements in four dual imaging methods (MRI/OI, MRI/PET, MRI/CT, MRI/US), aiming to guide future advancements in dual-modality molecular probes.
First-in-human Evaluation of Safety and Dosimetry of [Cu]FBP8: A fibrin-binding PET Probe.
Mol Imaging Biol
December 2024
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteen St. Suite 2301, Boston, MA, 02129, USA.
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- - The study investigates the safe use and distribution of a new imaging probe called [Cu]Fibrin Binding Probe #8 ([Cu]FBP8) in healthy individuals, focusing on its potential for thrombus imaging and pulmonary fibrosis detection.
- - Eight participants underwent PET/MRI sessions after receiving the probe, which showed quick blood clearance and renal excretion, with the urinary bladder and kidneys receiving the highest radiation doses.
- - Findings suggest that [Cu]FBP8 has low dosimetry, rapid clearance, and low background signal, making it a promising tool for non-invasive imaging in various medical conditions related to cardiovascular, cancer, and neurological issues.
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