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Background: The effects of physical activity (PA) across different domains and intensities on depressive symptoms remain inconclusive. Incorporating the community-built environment (CBE) into longitudinal analyses of PA's impact on depressive symptoms is crucial.

Objective: This study aims to examine the effects of PA at different intensities-low-intensity PA (eg, walking activities) and moderate-to-vigorous-intensity PA (eg, activities requiring substantial effort and causing faster breathing or shortness of breath)-across leisure-time and occupational domains on depressive symptom trajectories among middle-aged and older adults.

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Background: Chronic diseases are the leading cause of mortality and morbidity worldwide. Much of this burden can be prevented by adopting healthy behaviours and reducing chronic disease risk factors. Settings-based approaches to address chronic disease risk factors are recommended globally.

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Clinical trials have shown favorable effects of exercise on frailty, supporting physical activity (PA) as a treatment and prevention strategy. Proteomics studies suggest that PA alters levels of many proteins, some of which may function as molecules in the biological processes underlying frailty. However, these studies have focused on structured exercise programs or cross-sectional PA-protein associations.

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What Is Already Known On This Topic?: Physical activity (PA) and sedentary behavior (SB) are crucial determinants of both physical and mental health outcomes. However, large-scale studies using objective measurements of these behaviors have not been widely implemented across China.

What Is Added By This Report?: Based on World Health Organization guidelines, 56.

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Although intention is a strong predictor of moderate-to-vigorous intensity physical activity (MVPA), several factors moderate the intention-behavior relationship. People experience goal conflict when one of their goals makes it more difficult to pursue other goals. Goal conflict was examined as a moderator of the intention-behavior relation using data from ecological momentary assessments and accelerometer-derived estimates of MVPA.

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