Anaphylactoid reaction after use of intracervical dinoprostone gel.

Anaphylactic-like reaction or anaphylactoid reaction resembles generalized anaphylaxis but is not caused by immunoglobulin E-mediated allergic reaction. This reaction is caused by a non-immunologic mechanism even after first exposure to antigen. Prostaglandin E2 (dinoprostone) gel is commonly used for pre-induction cervical ripening. We report a case of anaphylactiod reaction after insertion of prostaglandin E2 gel for induction of labor. Hyperstimulation with dinoprostone gel is reported in the literature. An isolated report of three cases of anaphylactiod reaction after intracervical dinoprostone gel was found during a literature search. We are reporting this case for its rarity. As a potentially life-threatening condition, every obstetrician should be aware of this rare complication of dinoprostone gel.