AI Article Synopsis
- - L-amino acid oxidases are enzymes found in snake venoms that contribute to their toxicity mainly through their enzymatic activity, but other potential mechanisms are still being researched.
- - These enzymes have significant biological effects, such as influencing platelet aggregation, triggering cell death (apoptosis), causing hemorrhage, and exhibiting cytotoxic properties.
- - The review discusses the biochemical characteristics of snake venom L-amino acid oxidases, their relationships between structure and activity, and the different mechanisms of action that have been proposed.
Article Abstract
L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971498 | PMC |
| http://dx.doi.org/10.1155/2014/196754 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multienzyme cascade for synthesis of hydroxytyrosol via engineered Escherichia coli.
Sci Rep
January 2025
Dabie Mountain Laboratory, College of Tea and Food Science, Xinyang Normal University, Xinyang, 464000, Henan, China.
Hydroxytyrosol, a fine chemical, is widely utilized in food and pharmaceutical industries. In this study, we constructed a pathway to produce hydroxytyrosol by co-expressing tyrosin-phenol lyase (TPL), L-amino acid dehydrogenase (aadL), α-keto acid decarboxylase (KAD), aldehyde reductase (yahK) and glucose dehydrogenase (gdh). We changed combinations between plasmids with different copy numbers and target genes, resulting in 84% increase in hydroxytyrosol production.
View Article and Find Full Text PDFUsing Agaricus bisporus crude extract in distance based 3D microfluidic paper-based analytical device and spectrophotometric analytical procedures for thiols determination.
Talanta
December 2024
Analytical Chemistry Division, Chemistry Department, Lomonosov Moscow State University, 119234, Moscow, Russia. Electronic address:
Novel and simple spectrophotometric and distance based procedures for thiols (L-cysteine, N-acetylcysteine, and glutathione) determination in biological fluids and pharmaceuticals have been proposed based on their inhibitory action on the oxidation of catechol in the presence of Agaricus bisporus crude extract (ABE). The influence of L-glycine, L-alanine, L-proline, L-methionine, L-cystine, ascorbic acid, uric acid, and bilirubin on the thiol determination has been investigated. Uric acid, bilirubin, L-cystine (oxidized thiol), and L-amino acids do not interfere with the determination.
View Article and Find Full Text PDFThe Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies.
Toxins (Basel)
December 2024
School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India.
The intricate combination of organic and inorganic compounds found in snake venom includes proteins, peptides, lipids, carbohydrates, nucleotides, and metal ions. These components work together to immobilise and consume prey through processes such as paralysis and hypotension. Proteins, both enzymatic and non-enzymatic, form the primary components of the venom.
View Article and Find Full Text PDFMultifunctional cyclic biomimetic peptides: Self-assembling nanotubes for effective treatment of sepsis.
Int J Biol Macromol
December 2024
Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address:
Antibiotic abuse has led to an increasingly serious risk of antimicrobial resistance, developing alternative antimicrobials to combat this alarming issue is urgently needed. Rhesus theta defensin-1 (RTD-1) is a theta-defensin contributing to broad-spectrum bactericidal activity via the mechanisms of membrane perturbation. Intriguingly, human defensin-6 (HD6), an enteric defensin secreted by Paneth cells without direct bactericidal effect, could self-assembled into fibrous networks to trap enteric pathogens for assistance of innate immunity.
View Article and Find Full Text PDFMicroRNA-122 regulates inflammatory and autophagic proteins by downregulating pyruvate kinase M2 in non-alcoholic fatty liver disease.
Mol Cell Biochem
December 2024
Faculty of Life Sciences and Biotechnology, South Asian University, Rajpur Road, Maidan Garhi, New Delhi, India.
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is a major global health issue that can progress to more serious conditions like non-alcoholic steatohepatitis (NASH) and liver cancer (HCC), but the underlying molecular mechanisms are still not fully understood.
- This study focuses on how microRNA-122 regulates pyruvate kinase M2 (PKM2) and its impact on inflammatory and autophagic proteins during NAFLD development using both cell cultures and animal models.
- Results indicate that free fatty acids (FFAs) reduce miR-122 levels, leading to increased PKM2 and inflammation while suppressing proteins related to autophagy, highlighting the complex interactions that contribute to NA
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!