AI Article Synopsis
- Vemurafenib, a BRAF inhibitor approved for melanoma treatment, has greatly improved survival rates compared to traditional therapies and initially did not show kidney-related side effects.
- A case series involving 8 patients has revealed that vemurafenib can lead to severe renal insufficiency in some individuals.
- It is important to monitor kidney function closely in patients undergoing vemurafenib treatment to catch any potential renal issues early on, as further research is needed to understand its effects on the kidneys.
Article Abstract
Background: Vemurafenib is a BRAF inhibitor that has become the cornerstone of metastatic or inoperable melanoma therapy since its approval in 2011 in the United States and 2012 in Europe. This targeted therapy has shown impressive results in terms of increased progression-free and overall survival as compared to dacarbazine. The safety profile did not include any renal manifestations at that time.
Methods: This report is the first case series of 8 patients who experienced significant to severe renal insufficiency under vemurafenib treatment.
Results: This case series shows that vemurafenib may induce potentially severe acute renal failure, including renal sequelae and persistent kidney disease in some cases.
Conclusions: Further studies are needed to investigate the effects of vemurafenib on the kidneys. Meanwhile, renal function should be closely monitored in treated patients for early detection of any renal dysfunction occurrence. Cancer 2014;120:2158-2163. © 2014 American Cancer Society.
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| http://dx.doi.org/10.1002/cncr.28709 | DOI Listing |
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