AI Article Synopsis
- The study investigated the prevalence and prognostic significance of gene gains (SOX2, PIK3CA, FGFR1, and BRF2) in patients with non-small cell lung cancer (NSCLC) who underwent surgery.
- Gene copy number increases were found in a portion of cases: SOX2 (23.6%), PIK3CA (29.2%), FGFR1 (16.6%), and BRF2 (14.9%), with correlations to smoking history and cancer type.
- Increased SOX2 copy number was identified as a favorable prognostic factor for early stage NSCLC, particularly in stages I-II, indicating its potential role in future treatment strategies.
Article Abstract
Background: We aimed to investigate prevalence and prognostic role of SOX2, PIK3CA, FGFR1 and BRF2 gene gain in patients with surgically resected non-small cell lung cancer (NSCLC).
Methods: SOX2, PIK3CA, FGFR1 and BRF2 gene copy number was assessed by fluorescence in situ hybridization (FISH) in arrayed tissue cores from 447 resected NSCLCs.
Results: Increased gene copy number (FISH+) for SOX2, PIK3CA, FGFR1 and BRF2 was observed in 23.6%, 29.2%, 16.6% and 14.9% of cases, respectively. FISH+ status for each gene was significantly associated with smoking history, squamous cell carcinoma (SCC) histology, and increased copy number of the other studied genes. Multivariate analysis of overall survival indicated increased SOX2 gene copy number (P = 0.008), stage I-II (P<0.001), and adenocarcinoma or SCC histology (P = 0.016) as independent, favorable prognostic factors. A statistically significant interaction was observed between stage and SOX2 gene status (P = 0.021), indicating that the prognostic impact of SOX2 gene gain differs across stages and is limited to patients with stage I-II disease (HR 0.44, 95% CI: 0.25-0.77; P = 0.004, adjusted for histology).
Conclusions: Increased SOX2 gene copy number is an independent and favorable prognostic factor in surgically resected, early stage NSCLC, regardless of histology. SOX2, PIK3CA, FGFR1 and BRF2 gene gains are likely to occur concurrently, with potentially relevant implications for the development of new therapeutic strategies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988173 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095303 | PLOS |
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