Polyfunctional molecules were prepared by appropriate conjugation of three moities (1) a polyion-immunostimulant (copolymer of N-vinylpyrrolidone with vinylamine-VP/VA), (2) an inhibitor of mediator secretion from mast cells (diphenylquinone-DPQ) and (3) a specific allergen (ovalbumin-OV). The conjugate of VP/VA with DPQ dose-dependently inhibited histamine release from rat and mouse mast cells induced by the selective releasing agents compound 48/80, ionophore A23187 and specific allergen. The DPQ bound to the polyion was responsible for the inhibitory action of the conjugate. OV conjugated with VP/VA/DPQ (VP/VA/DPQ-OV) was a weaker histamine releaser than OV alone. An immunoenzymatic assay showed that the reduction of the histamine releasing activity of OV in the conjugate was not connected with an inhibition of the antibody binding activity of the OV. The data here presented demonstrate the possibility of creating a polyfunctional molecule (for e.g. hyposensitization) with a decreased ability to induce allergic reactions by inserting a functional group which inhibits histamine secretion into the molecule.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF02222203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyfunctional CD8CD226RUNX2 effector T cells are diminished in advanced stages of chronic lymphocytic leukemia.
Mol Oncol
January 2025
Division of Foundational Sciences, Mike Petryk School of Dentistry, University of Alberta, Edmonton, Canada.
CD8 T cells, a subset of T cells identified by the surface glycoprotein CD8, particularly those expressing the co-stimulatory molecule CD226, play a crucial role in the immune response to malignancies. However, their role in chronic lymphocytic leukemia (CLL), an immunosuppressive disease, has not yet been explored. We studied 64 CLL patients and 25 age- and sex-matched healthy controls (HCs).
View Article and Find Full Text PDFImmunogenicity of the CoronaVac vaccine in children: a real-world study.
Front Immunol
January 2025
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.
Background: Despite its proven effectiveness and safety, there are limited real-world data on CoronaVac's immunogenicity in children, especially in lower-income countries, particularly for SARS-CoV-2 variants. We present a real-world study evaluating CoronaVac's immunogenicity in Colombian children stratified by previous exposure to this virus.
Methods: 89 children aged 3-11 years were enrolled (50 Non-Exposed and 39 Exposed).
Unimolecular net heterolysis of symmetric and homopolar σ-bonds.
Nature
August 2024
Institut für Organische Chemie, Fakultät für Chemie und Pharmazie, Universität Regensburg, Regensburg, Germany.
The unimolecular heterolysis of covalent σ-bonds is integral to many chemical transformations, including S1-, E1- and 1,2-migration reactions. To a first approximation, the unequal redistribution of electron density during bond heterolysis is governed by the difference in polarity of the two departing bonding partners. This means that if a σ-bond consists of two identical groups (that is, symmetric σ-bonds), its unimolecular fission from the S, S, or T states only occurs homolytically after thermal or photochemical activation.
View Article and Find Full Text PDFIntravenous BCG induces a more potent airway and lung immune response than intradermal BCG in SIV-infected macaques.
bioRxiv
July 2024
Department of Microbiology and Molecular Genetics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Tuberculosis (TB), caused by (Mtb), is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates Mtb infection outcomes in people living with HIV (PLWH). Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in infants, but its efficacy in adolescents and adults is limited.
View Article and Find Full Text PDFPublic T cell clonotypes are selected in HLA-B57:01/HIV patients independently of the viral load.
Cell Rep
August 2024
Immunity and Infection Program, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, VIC 3086, Australia; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3086, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia. Electronic address:
HIV controllers can control viral replication and remain healthy, but the mechanism behind this control is unknown. Despite human leukocyte antigen (HLA) diversity in the population, almost 50% of HIV controllers express the HLA-B57:01 molecule, which presents, among others, the Gag-derived epitope TW10. Given TW10's presentation in early infection, TW10-specific T cells could participate in the control of HIV.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!