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Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.
Pak J Pharm Sci
March 2025
Department of Cardiology, the Third Affiliated Hospital of Qiqihar Medical College, China.
To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).
View Article and Find Full Text PDFComparative study on the drug effects and adverse reactions of doxycycline and isotretinoin in the treatment of moderate to severe acne.
Pak J Pharm Sci
March 2025
Department of Plastic and Cosmetic Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
To compare the drug effects and adverse reactions of doxycycline and isotretinoin in patients with moderate to severe acne. A retrospective analysis was conducted on 98 patients with moderate to severe acne who were treated in the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from June 2020 to June 2023. They were divided into group A and group B based on actual medication use, with 49 cases in each group.
View Article and Find Full Text PDFNormothermic Machine Perfusion Improves Outcomes for Donation After Cardiac Death Allografts With Extended Donor Warm Ischemia Time.
Clin Transplant
March 2025
Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Introduction: Donation after circulatory death (DCD) allografts are underutilized in liver transplantation (LT) due to increased risk of complications. These risks stem from ischemic injury sustained during the total donor warm ischemia time (tDWIT), historically limited to 30 min. Normothermic machine perfusion (NMP) can mitigate these risks and facilitate LT of DCD grafts with extended tDWIT.
View Article and Find Full Text PDFDifferentiated thyroid carcinoma (DTC) is the most common endocrine cancer, accounting for 90-95% of thyroid malignancy and predominant in the female population of all age groups. Surgery is the standard primary treatment for patients with DTC, followed by radioactive iodine therapy (RAIT) when indicated. After the main treatment, patients receive thyroid hormone therapy in a variety of regimens, either as a replacement therapy or as a therapy intended to suppress secretion of thyroid-stimulating hormone (TSH).
View Article and Find Full Text PDFTargeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers.
Adv Sci (Weinh)
March 2025
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Synthetic lethality in homologous recombination (HR)-deficient cancers caused by Poly (ADP-ribose) polymerase inhibitors (PARPi) has been classically attributed to its role in DNA repair. The mode of action of PARPi and resistance thereof are now believed to be predominantly replication associated. Therefore, effective combinatorial approaches of targeting replication fork processing along with HR-downregulation to target HR-proficient and possibly PARPi-resistant tumors are warranted.
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