AI Article Synopsis
- C-terminal tensin-like (cten) is part of the tensin family, localized mainly at focal adhesion sites and has unique features in its structure.
- Cten is highly expressed in healthy prostate and placenta tissues but is reduced in prostate cancer; however, its overexpression is linked to several cancer types, including breast and lung cancers.
- Increased levels of cten enhance cell movement and tumor growth, suggesting it could be an important biomarker and target for cancer treatment.
Article Abstract
C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038153 | PMC |
| http://dx.doi.org/10.1016/j.biocel.2014.04.003 | DOI Listing |
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