A dianionic Ireland-Claisen rearrangement of chiral, nonracemic α-methyl-β-hydroxy allylic esters has been developed that proceeds with high diastereoselectivity and provides products containing three contiguous stereogenic carbons, including a quaternary center. The potential utility of the rearrangement for complex molecule synthesis is also demonstrated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018138 | PMC |
| http://dx.doi.org/10.1021/ol5008422 | DOI Listing |
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