First of all, the history and development of Birstonas, a health resort by the river Neman, near Vilnius, first mentioned in 1382, are recounted in detail. The value of this health resort was determined by a mild climate and salt springs. Information on Birstonas by Władysław Syrokomla (1823-1862), the Polish poet, and Zygmunt Gloger (1845-1910), the Polish ethnographer, archaeologist and historian are well known. The indications and contraindications in many diseases, and the effects of treatment in this health resort are described. Finally, the opportunities for recreation and the attractions in this charming health resort are presented. Attention was paid to the leading role of Poles in the development of this health resort now in Lithuania. The biographies of several physicians practicing in Birstonas: Jan Sokołowski, Aleksander T.W. Korewa, Anicety Renier, Stanisław K. Wikszemski, Benedykt Bilifiski, Erminio Andriolli, Roman Przybylski and Paweł A. Sawicki are presented. Their biographies, professional achievements and work in Birstonas are depicted in detail.
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Microb Pathog
January 2025
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Following a period of disuse owing to the emergence of multidrug-resistant Gram-negative bacteria, colistin has regained global attention as an antibiotic of last resort. The resurgence in its utilization has led to a concurrent increase in acquired resistance, presenting a significant challenge in clinical treatment. Predominantly, resistance mechanisms involve alterations in the lipid A component of the lipopolysaccharide (LPS) structure.
View Article and Find Full Text PDFMicroorganisms
January 2025
Department of Medical Microbiology "Corr. Mem. Prof. Ivan Mitov, MD, DMSc", Faculty of Medicine, Medical University of Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria.
Linezolid is an oxazolidinone antibiotic and is considered a last-resort treatment option for serious infections caused by problematic Gram-positive pathogens, including vancomycin-resistant enterococci. The present study aimed to explore the linezolid resistance mechanisms and genomic characteristics of two vancomycin-susceptible isolates from Bulgaria. The strains designated Efs2503-bg (inpatient from Pleven) and Efs966-bg (outpatient from Varna) were recovered from wounds in 2018 and 2023, respectively.
View Article and Find Full Text PDFMicroorganisms
January 2025
Laboratório de Epidemiologia e Microbiologia Moleculares-LEMiMo, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos 13563-120, SP, Brazil.
KPC is a clinically significant serine carbapenemase in most countries, and its rapid spread threatens global public health. transmission is commonly mediated by Tn transposons. The gene has also been found in (NTE).
View Article and Find Full Text PDFHealthcare (Basel)
January 2025
Department of Physical Medicine, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.
Background/objectives: Among the neuropsychiatric symptoms of long COVID, the following may be listed: sleep disturbances, headaches, anxiety, depression, dizziness, numbness, memory loss, and concentration difficulties. Various therapies have been implemented to mitigate these symptoms; however, health resort treatments that utilize a wide range of modalities stimulating multidirectional biological reactions may also be effective. The aim of this study was to assess the severity of neuropsychiatric symptoms in long COVID patients who qualified for health resort treatment, evaluate the effectiveness of health resort treatment in this group of patients, and evaluate the effect of balneological factors in the treatment course.
View Article and Find Full Text PDFRegul Toxicol Pharmacol
January 2025
Corteva Agriscience, Zuid-Oostsingel 24D, Bergen op Zoom, 4611 BB, the Netherlands.
Environmental Safety Assessments (ESA) are mandatory for several regulatory purposes and are an important component of stewardship/sustainability initiatives. Fish testing is used for assessing chemical toxicity and bioaccumulation potential; amphibians are included in some jurisdictions and their use is increasing to assess endocrine disruption. Alternative methods are becoming more available, covering the principles of the 3Rs (i.
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